138D
| A-DNA DECAMER D(GCGGGCCCGC)-HEXAGONAL CRYSTAL FORM | 分子名称: | DNA (5'-D(*GP*CP*GP*GP*GP*CP*CP*CP*GP*C)-3') | 著者 | Ramakrishnan, B, Sundaralingam, M. | 登録日 | 1993-09-15 | 公開日 | 1994-01-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Evidence for crystal environment dominating base sequence effects on DNA conformation: crystal structures of the orthorhombic and hexagonal polymorphs of the A-DNA decamer d(GCGGGCCCGC) and comparison with their isomorphous crystal structures. Biochemistry, 32, 1993
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1D60
| THE STRUCTURE OF THE B-DNA DECAMER C-C-A-A-C-I-T-T-G-G: TRIGONAL FORM | 分子名称: | DNA (5'-D(*CP*CP*AP*AP*CP*IP*TP*TP*GP*G)-3'), MAGNESIUM ION | 著者 | Lipanov, A, Kopka, M.L, Kaczor-Grzeskowiak, M, Quintana, J, Dickerson, R.E. | 登録日 | 1992-02-26 | 公開日 | 1993-04-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of the B-DNA decamer C-C-A-A-C-I-T-T-G-G in two different space groups: conformational flexibility of B-DNA. Biochemistry, 32, 1993
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2HID
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1AGL
| STRUCTURE OF A DNA-BISDAUNOMYCIN COMPLEX | 分子名称: | 4-METHYLBENZYL-N-BIS[DAUNOMYCIN], DNA (5'-D(*CP*GP*AP*TP*CP*G)-3') | 著者 | Hu, G.G, Shui, X, Leng, F, Priebe, W, Chaires, J.B, Williams, L.D. | 登録日 | 1997-03-25 | 公開日 | 1997-04-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of a DNA-bisdaunomycin complex. Biochemistry, 36, 1997
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8D8I
| Crystal structure of Reverb alpha in complex with synthetic agonist | 分子名称: | (4S)-6-[([1,1'-biphenyl]-2-yl)oxy]-3-chloro[1,2,4]triazolo[4,3-b]pyridazine, Nuclear receptor corepressor 1, Nuclear receptor subfamily 1 group D member 1 | 著者 | Ronin, C, Ciesielski, F, Hegazy, L, Burris, P.T. | 登録日 | 2022-06-08 | 公開日 | 2022-12-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.504 Å) | 主引用文献 | Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB. Nat Commun, 13, 2022
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1D56
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1CR3
| SOLUTION CONFORMATION OF THE (+)TRANS-ANTI-BENZO[G]CHRYSENE-DA ADDUCT OPPOSITE DT IN A DNA DUPLEX | 分子名称: | BENZO[G]CHRYSENE, DNA (5'-D(*CP*TP*CP*TP*CP*AP*CP*TP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*TP*GP*AP*GP*AP*G)-3') | 著者 | Suri, A.K, Mao, B, Amin, S, Geacintov, N.E, Patel, D.J. | 登録日 | 1999-08-12 | 公開日 | 2000-02-18 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution conformation of the (+)-trans-anti-benzo[g]chrysene-dA adduct opposite dT in a DNA duplex. J.Mol.Biol., 292, 1999
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8T2H
| DYRK1A complex with DYR530 | 分子名称: | (4P)-4-{(3M)-3-[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl}pyridin-2-amine, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, GLYCEROL, ... | 著者 | Montfort, W.R, Basantes, L.E. | 登録日 | 2023-06-06 | 公開日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of DYR684, a Potent, Selective, Metabolically Stable, DYRK1A/B PROTAC utilizing a Novel Cereblon Molecular Glue To Be Published
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1D57
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1NTR
| SOLUTION STRUCTURE OF THE N-TERMINAL RECEIVER DOMAIN OF NTRC | 分子名称: | NTRC RECEIVER DOMAIN | 著者 | Volkman, B.F, Nohaile, M.J, Amy, N.K, Kustu, S, Wemmer, D.E. | 登録日 | 1994-09-16 | 公開日 | 1995-01-26 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Three-dimensional solution structure of the N-terminal receiver domain of NTRC. Biochemistry, 34, 1995
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8T5B
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7ONJ
| Mechanosensitive channel MscS solubilized with LMNG in open conformation | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, DODECYL-BETA-D-MALTOSIDE, Lauryl Maltose Neopentyl Glycol, ... | 著者 | Rasmussen, T, Flegler, V.J, Boettcher, B. | 登録日 | 2021-05-25 | 公開日 | 2021-09-01 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Mechanosensitive channel gating by delipidation. Proc.Natl.Acad.Sci.USA, 118, 2021
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5OP4
| Structure of CHK1 10-pt. mutant complex with aminopyrimidine LRRK2 inhibitor | 分子名称: | Serine/threonine-protein kinase Chk1, [4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoranyl-5-methoxy-phenyl]-morpholin-4-yl-methanone | 著者 | Dokurno, P, Williamson, D.S, Acheson-Dossang, P, Chen, I, Murray, J.B, Shaw, T, Surgenor, A.E. | 登録日 | 2017-08-09 | 公開日 | 2017-10-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1). J. Med. Chem., 60, 2017
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7XA3
| Cryo-EM structure of the CCL2 bound CCR2-Gi complex | 分子名称: | C-C motif chemokine 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | 登録日 | 2022-03-17 | 公開日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discov, 8, 2022
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1D1Y
| BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,3-PBITU (H4B FREE) | 分子名称: | 1,2-ETHANEDIOL, 2-{2-[3-(2-CARBAMIMIDOYLSULFANYL-ETHYL)-PHENYL]-ETHYL}-ISOTHIOUREA, ACETATE ION, ... | 著者 | Raman, C.S, Li, H, Martasek, P, Southan, G.J, Masters, B.S.S, Poulos, T.L. | 登録日 | 1999-09-21 | 公開日 | 2001-07-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase. J.Biol.Chem., 276, 2001
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5OV5
| Bacillus megaterium porphobilinogen deaminase D82E mutant | 分子名称: | 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, Porphobilinogen deaminase | 著者 | Guo, J, Erskine, P, Coker, A.R, Wood, S.P, Cooper, J.B. | 登録日 | 2017-08-28 | 公開日 | 2017-09-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structural studies of domain movement in active-site mutants of porphobilinogen deaminase from Bacillus megaterium. Acta Crystallogr F Struct Biol Commun, 73, 2017
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1CWU
| BRASSICA NAPUS ENOYL ACP REDUCTASE A138G MUTANT COMPLEXED WITH NAD+ AND THIENODIAZABORINE | 分子名称: | 6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL, ENOYL ACP REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Roujeinikova, A, Rafferty, J.B, Rice, D.W. | 登録日 | 1999-08-26 | 公開日 | 1999-09-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Inhibitor binding studies on enoyl reductase reveal conformational changes related to substrate recognition. J.Biol.Chem., 274, 1999
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5OOR
| Structure of CHK1 10-pt. mutant complex with staurosporine | 分子名称: | CHLORIDE ION, STAUROSPORINE, Serine/threonine-protein kinase Chk1 | 著者 | Dokurno, P, Williamson, D.S, Acheson-Dossang, P, Chen, I, Murray, J.B, Shaw, T, Surgenor, A.E. | 登録日 | 2017-08-08 | 公開日 | 2017-10-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1). J. Med. Chem., 60, 2017
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1HDG
| THE CRYSTAL STRUCTURE OF HOLO-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM THE HYPERTHERMOPHILIC BACTERIUM THERMOTOGA MARITIMA AT 2.5 ANGSTROMS RESOLUTION | 分子名称: | HOLO-D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION | 著者 | Korndoerfer, I, Steipe, B, Huber, R, Tomschy, A, Jaenicke, R. | 登録日 | 1995-01-17 | 公開日 | 1995-03-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The crystal structure of holo-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima at 2.5 A resolution. J.Mol.Biol., 246, 1995
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1QCP
| CRYSTAL STRUCTURE OF THE RWJ-51084 BOVINE PANCREATIC BETA-TRYPSIN AT 1.8 A | 分子名称: | CALCIUM ION, CYCLOPENTANECARBOXYLIC ACID [1-(BENZOTHIAZOLE-2-CARBONYL)-4-GUANIDINO-BUTYL]-AMIDE, PROTEIN (BETA-TRYPSIN PROTEIN) | 著者 | Recacha, R, Carson, M, Costanzo, M.J, Maryanoff, B, Chattopadhyay, D. | 登録日 | 1999-05-10 | 公開日 | 1999-05-21 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of the RWJ-51084-bovine pancreatic beta-trypsin complex at 1.8 A. Acta Crystallogr.,Sect.D, 55, 1999
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2J89
| Functional and structural aspects of poplar cytosolic and plastidial type A methionine sulfoxide reductases | 分子名称: | BETA-MERCAPTOETHANOL, METHIONINE SULFOXIDE REDUCTASE A | 著者 | Rouhier, N, Kauffmann, B, Tete-Favier, F, Palladino, P, Gans, P, Branlant, G, Jacquot, J.P, Boschi-Muller, S. | 登録日 | 2006-10-23 | 公開日 | 2006-11-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Functional and Structural Aspects of Poplar Cytosolic and Plastidial Type a Methionine Sulfoxide Reductases J.Biol.Chem., 282, 2007
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8U5M
| Structure of Sts-1 HP domain with rebamipide | 分子名称: | Rebamipide, Ubiquitin-associated and SH3 domain-containing protein B | 著者 | Azia, F, Dey, R, French, J.B. | 登録日 | 2023-09-12 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins. J.Med.Chem., 67, 2024
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1NPQ
| structure of a rhodamine-labeled N-domain Troponin C mutant (Ca2+ saturated) in complex with skeletal Troponin I 115-131 | 分子名称: | CALCIUM ION, Troponin C, Troponin I | 著者 | Mercier, P, Ferguson, R.E, Irving, M, Corrie, J.E.T, Trentham, D.R, Sykes, B.D. | 登録日 | 2003-01-18 | 公開日 | 2003-04-29 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Structure of a Bifunctional Rhodamine Labeled N-Domain of Troponin C Complexed with the Regulatory
"Switch" Peptide from Troponin I: Implications for in Situ Fluorescence Studies in Muscle Fibers Biochemistry, 42, 2003
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5M5Q
| COPS5(2-257) IN COMPLEX WITH A AZAINDOLE (COMPOUND 4) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1-[(3~{R})-3-(1~{H}-benzimidazol-2-yl)morpholin-4-yl]-3-[2-(4-methyl-2-phenyl-phenyl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]propan-1-one, COP9 signalosome complex subunit 5, ... | 著者 | Renatus, M, Altmann, E. | 登録日 | 2016-10-22 | 公開日 | 2017-01-11 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5. Angew. Chem. Int. Ed. Engl., 56, 2017
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1DC0
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