8D8I

Crystal structure of Reverb alpha in complex with synthetic agonist

Summary for 8D8I

Entry DOI	10.2210/pdb8d8i/pdb
Descriptor	Nuclear receptor subfamily 1 group D member 1, Nuclear receptor corepressor 1, (4S)-6-[([1,1'-biphenyl]-2-yl)oxy]-3-chloro[1,2,4]triazolo[4,3-b]pyridazine, ... (4 entities in total)
Functional Keywords	rev-erb, nuclear receptor, agonist, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	29093.50
Authors	Ronin, C.,Ciesielski, F.,Hegazy, L.,Burris, P.T. (deposition date: 2022-06-08, release date: 2022-12-14, Last modification date: 2024-04-03)
Primary citation	Murray, M.H.,Valfort, A.C.,Koelblen, T.,Ronin, C.,Ciesielski, F.,Chatterjee, A.,Veerakanellore, G.B.,Elgendy, B.,Walker, J.K.,Hegazy, L.,Burris, T.P. Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB. Nat Commun, 13:7131-7131, 2022 Cited by PubMed: 36414641 DOI: 10.1038/s41467-022-34892-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.504 Å)

Structure validation