8D8I
Crystal structure of Reverb alpha in complex with synthetic agonist
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Nuclear receptor subfamily 1 group D member 1 | polymer | 237 | 26490.2 | 1 | UniProt (P20393) Pfam (PF00104) In PDB | Homo sapiens (human) | Rev-erbA-alpha,V-erbA-related protein 1,EAR-1 |
2 | B | Nuclear receptor corepressor 1 | polymer | 20 | 2280.6 | 1 | UniProt (O75376) In PDB | Homo sapiens (human) | N-CoR,N-CoR1 |
3 | A | (4S)-6-[([1,1'-biphenyl]-2-yl)oxy]-3-chloro[1,2,4]triazolo[4,3-b]pyridazine | non-polymer | 322.7 | 1 | Chemie (QFX) | |||
4 | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A: 281 - 424 (UniProt: P20393)
A: 425 - 614 (UniProt: P20393)
B: 2045 - 2064 (UniProt: O75376)
PDB | External Database | Details |
---|---|---|
Gly 277 | - | expression tag |
Ser 278 | - | expression tag |
His 279 | - | expression tag |
Met 280 | - | expression tag |
B: 2045 - 2064 (UniProt: O75376)
PDB | External Database | Details |
---|---|---|
Ala 2056 | Cys 2056 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 28770.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 322.7 | |
All* | Total formula weight | 29093.5 |