8D8I

Crystal structure of Reverb alpha in complex with synthetic agonist

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Nuclear receptor subfamily 1 group D member 1	polymer	237	26490.2	1	UniProt (P20393) Pfam (PF00104)	Homo sapiens (human)	Rev-erbA-alpha,V-erbA-related protein 1,EAR-1
2	B (B)	Nuclear receptor corepressor 1	polymer	20	2280.6	1	UniProt (O75376)	Homo sapiens (human)	N-CoR,N-CoR1
3	C (A)	(4S)-6-[([1,1'-biphenyl]-2-yl)oxy]-3-chloro[1,2,4]triazolo[4,3-b]pyridazine	non-polymer		322.7	1	Chemie (QFX)
4	D (A)	water	water		18.0	26	Chemie (HOH)

Sequence modifications

A: 281 - 424 (UniProt: P20393)

PDB	External Database	Details
Gly 277	-	expression tag
Ser 278	-	expression tag
His 279	-	expression tag
Met 280	-	expression tag

A: 425 - 614 (UniProt: P20393)
B: 2045 - 2064 (UniProt: O75376)

PDB	External Database	Details
Ala 2056	Cys 2056	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	28770.8
Non-Polymers*	Number of molecules	1
	Total formula weight	322.7
All*	Total formula weight	29093.5

*Water molecules are not included.