8T5B

HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor EKC-110

Summary for 8T5B

• Entry DOI: 10.2210/pdb8t5b/pdb
• Descriptor: Integrase, (2S)-tert-butoxy{4-(4-chlorophenyl)-2,6-dimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: integrase, viral protein
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 4
• Total formula weight: 48182.74

Authors

Dinh, T.,Kvaratskhelia, M. (deposition date: 2023-06-12, release date: 2024-06-19)

• Primary citation: Dinh, T.,Kvaratskhelia, M.; Understanding the resistance of Y99H and A128T mutations in HIV-1 Integrase against the effective anti-HIV drugs of STP0404 and BKC11; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.08 Å)