8T2H

DYRK1A complex with DYR530

Summary for 8T2H

• Entry DOI: 10.2210/pdb8t2h/pdb
• Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, (4P)-4-{(3M)-3-[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl}pyridin-2-amine, TETRAETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: kinase, inhibitor, alzheimer's disease, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 86183.04

Authors

Montfort, W.R.,Basantes, L.E. (deposition date: 2023-06-06, release date: 2024-05-15)

• Primary citation: Montfort, W.R.,Basantes, L.E.; Discovery of DYR684, a Potent, Selective, Metabolically Stable, DYRK1A/B PROTAC utilizing a Novel Cereblon Molecular Glue; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)