5M5Q

COPS5(2-257) IN COMPLEX WITH A AZAINDOLE (COMPOUND 4)

Summary for 5M5Q

Entry DOI	10.2210/pdb5m5q/pdb
Descriptor	COP9 signalosome complex subunit 5, ZINC ION, 1-[(3~{R})-3-(1~{H}-benzimidazol-2-yl)morpholin-4-yl]-3-[2-(4-methyl-2-phenyl-phenyl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]propan-1-one, ... (5 entities in total)
Functional Keywords	metal protease, cop9 signalosome, hydroxylase, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q92905
Total number of polymer chains	1
Total formula weight	29676.20
Authors	Renatus, M.,Altmann, E. (deposition date: 2016-10-22, release date: 2017-01-11, Last modification date: 2017-01-25)
Primary citation	Altmann, E.,Erbel, P.,Renatus, M.,Schaefer, M.,Schlierf, A.,Druet, A.,Kieffer, L.,Sorge, M.,Pfister, K.,Hassiepen, U.,Jones, M.,Ruedisser, S.,Ostermeier, D.,Martoglio, B.,Jefferson, A.B.,Quancard, J. Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5. Angew. Chem. Int. Ed. Engl., 56:1294-1297, 2017 Cited by PubMed: 27981705 DOI: 10.1002/anie.201608672 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation