8TAL
| TMEM16F, with Calcium and PIP2, no inhibitor, Cl1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION | 著者 | Wu, H, Feng, S, Cheng, Y. | 登録日 | 2023-06-27 | 公開日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
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8SUR
| TMEM16F bound with Niclosamide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, ... | 著者 | Feng, S, Cheng, Y. | 登録日 | 2023-05-13 | 公開日 | 2023-09-06 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
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8TAG
| TMEM16F, with Calcium and PIP2, no inhibitor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION | 著者 | Feng, S, Cheng, Y. | 登録日 | 2023-06-27 | 公開日 | 2023-09-06 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
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2N13
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8SMS
| Crosslinked Crystal Structure of Type II Fatty Acid Synthase, FabB, and cerulenin crosslinker-crypto Acyl Carrier Protein, AcpP | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-{2-[(2R)-2-hydroxy-4-oxododecanamido]ethyl}-beta-alaninamide | 著者 | Jiang, Z, Chen, A, Chen, J, Sekhon, A, Louie, G.V, Noel, J.P, La Clair, J.J, Burkart, M.D. | 登録日 | 2023-04-26 | 公開日 | 2023-09-27 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Masked cerulenin enables a dual-site selective protein crosslink. Chem Sci, 14, 2023
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8TCF
| Integrin alpha-v beta-8 in complex with minibinder B8_BP_dsulf | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Campbell, M.G, Fernandez, A, Roy, A, Kraft, J, Baker, D. | 登録日 | 2023-06-30 | 公開日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8. Nat Commun, 14, 2023
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8SJ7
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8TCG
| Integrin alpha-v beta-6 in complex with minibinder B6_BP_dslf | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-V heavy chain, ... | 著者 | Campbell, M.G, Fernandez, A, Roy, A, Kraft, J, Baker, D. | 登録日 | 2023-06-30 | 公開日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8. Nat Commun, 14, 2023
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8TAH
| Cryo-EM structure of Cortactin-bound to Arp2/3 complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1A, ... | 著者 | Fregoso, F.E, van Eeuwen, T, Dominguez, R. | 登録日 | 2023-06-27 | 公開日 | 2023-09-27 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins. Nat Commun, 14, 2023
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8TDM
| Cryo-EM structure of AtMSL10-K539E | 分子名称: | Mechanosensitive ion channel protein 10 | 著者 | Zhang, J, Yuan, P. | 登録日 | 2023-07-03 | 公開日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10. Nat Commun, 14, 2023
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8TB7
| Cryo-EM Structure of GPR61- | 分子名称: | 6-{[(3,5-difluoropyridin-4-yl)methyl]amino}-N-(4-ethoxy-6-methylpyrimidin-2-yl)-2-methoxy-N-(2-methoxyethyl)pyridine-3-sulfonamide, Fab hinge-binding nanobody, Fab24 BAK5 heavy chain, ... | 著者 | Lees, J.A, Dias, J.M, Han, S. | 登録日 | 2023-06-28 | 公開日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Nat Commun, 14, 2023
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8TB0
| Cryo-EM Structure of GPR61-G protein complex stabilized by scFv16 | 分子名称: | GPR61 fused to dominant negative G alpha S/I N18 chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Lees, J.A, Dias, J.M, Han, S. | 登録日 | 2023-06-28 | 公開日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Nat Commun, 14, 2023
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2N0Z
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8TDJ
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8SOT
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8SSC
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8TDK
| Cryo-EM structure of AtMSL10-G556V | 分子名称: | Mechanosensitive ion channel protein 10 | 著者 | Zhang, J, Yuan, P. | 登録日 | 2023-07-03 | 公開日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10. Nat Commun, 14, 2023
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8TDL
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8SV8
| Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex from a composite map | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | 著者 | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | 登録日 | 2023-05-15 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
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8SSD
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8SUN
| TMEM16F 1PBC | 分子名称: | 1-Hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, ... | 著者 | Wu, H, Feng, S, Cheng, Y. | 登録日 | 2023-05-12 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
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8SUK
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8T5Y
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8SV6
| Structure of the M. smegmatis DarR protein | 分子名称: | Fatty acid metabolism regulator protein | 著者 | Schumacher, M.A. | 登録日 | 2023-05-15 | 公開日 | 2023-11-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.56 Å) | 主引用文献 | Structures of the DarR transcription regulator reveal unique modes of second messenger and DNA binding. Nat Commun, 14, 2023
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7RBR
| The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with a Lys48-linked di-ubiquitin | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Papain-like protease, ... | 著者 | Osipiuk, J, Tesar, C, Endres, M, Lanham, B.T, Wydorski, P, Fushman, D, Joachimiak, L, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-07-06 | 公開日 | 2021-09-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin. Nat Commun, 14, 2023
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