8TCF

Integrin alpha-v beta-8 in complex with minibinder B8_BP_dsulf

Summary for 8TCF

Entry DOI	10.2210/pdb8tcf/pdb
EMDB information	41153
Descriptor	Integrin alpha-V heavy chain, Integrin beta-8, Minibinder B8_BP_dslf, ... (8 entities in total)
Functional Keywords	complex, heterodimer, signaling, tgf-beta, de novo protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	100616.99
Authors	Campbell, M.G.,Fernandez, A.,Roy, A.,Kraft, J.,Baker, D. (deposition date: 2023-06-30, release date: 2023-09-27)
Primary citation	Roy, A.,Shi, L.,Chang, A.,Dong, X.,Fernandez, A.,Kraft, J.C.,Li, J.,Le, V.Q.,Winegar, R.V.,Cherf, G.M.,Slocum, D.,Poulson, P.D.,Casper, G.E.,Vallecillo-Zuniga, M.L.,Valdoz, J.C.,Miranda, M.C.,Bai, H.,Kipnis, Y.,Olshefsky, A.,Priya, T.,Carter, L.,Ravichandran, R.,Chow, C.M.,Johnson, M.R.,Cheng, S.,Smith, M.,Overed-Sayer, C.,Finch, D.K.,Lowe, D.,Bera, A.K.,Matute-Bello, G.,Birkland, T.P.,DiMaio, F.,Raghu, G.,Cochran, J.R.,Stewart, L.J.,Campbell, M.G.,Van Ry, P.M.,Springer, T.,Baker, D. De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8. Nat Commun, 14:5660-5660, 2023 Cited by PubMed: 37704610 DOI: 10.1038/s41467-023-41272-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation