8SMS

Crosslinked Crystal Structure of Type II Fatty Acid Synthase, FabB, and cerulenin crosslinker-crypto Acyl Carrier Protein, AcpP

Summary for 8SMS

Entry DOI	10.2210/pdb8sms/pdb
Descriptor	3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-{2-[(2R)-2-hydroxy-4-oxododecanamido]ethyl}-beta-alaninamide, ... (4 entities in total)
Functional Keywords	ketosynthase, fabb, acpp, acyl carrier protein, cerulenin, crosslinker, crosslink, fatty acid biosynthesis, natural product, biosynthetic protein
Biological source	Escherichia coli K-12 More
Total number of polymer chains	4
Total formula weight	103327.95
Authors	Jiang, Z.,Chen, A.,Chen, J.,Sekhon, A.,Louie, G.V.,Noel, J.P.,La Clair, J.J.,Burkart, M.D. (deposition date: 2023-04-26, release date: 2023-09-27, Last modification date: 2023-10-25)
Primary citation	Jiang, Z.,Chen, A.,Chen, J.,Sekhon, A.,Louie, G.V.,Noel, J.P.,La Clair, J.J.,Burkart, M.D. Masked cerulenin enables a dual-site selective protein crosslink. Chem Sci, 14:10925-10933, 2023 Cited by PubMed: 37829009 DOI: 10.1039/d3sc02864j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation