8SUR

TMEM16F bound with Niclosamide

Summary for 8SUR

• Entry DOI: 10.2210/pdb8sur/pdb
• EMDB information: 40776
• Descriptor: Anoctamin-6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: ca2+-activated ion channels and lipid scramblases, membrane protein
• Biological source: Mus musculus (mouse)
• Total number of polymer chains: 2
• Total formula weight: 214775.39

Authors

Feng, S.,Cheng, Y. (deposition date: 2023-05-13, release date: 2023-09-06, Last modification date: 2023-11-01)

• Primary citation: Feng, S.,Puchades, C.,Ko, J.,Wu, H.,Chen, Y.,Figueroa, E.E.,Gu, S.,Han, T.W.,Ho, B.,Cheng, T.,Li, J.,Shoichet, B.,Jan, Y.N.,Cheng, Y.,Jan, L.Y.; Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.; Nat Commun, 14:4874-4874, 2023; PubMed: 37573365; DOI: 10.1038/s41467-023-40410-x

Experimental method

ELECTRON MICROSCOPY (3.1 Å)