4ZIE
 
 | | Crystal Structure of core/latch dimer of Bax in complex with BimBH3 | | 分子名称: | 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2-like protein 11 | | 著者 | Krishna Kumar, K, Robin, A.Y, Westphal, D, Wardak, A.Z, Thompson, G.V, Dewson, G, Colman, P.M, Czabotar, P.E. | | 登録日 | 2015-04-28 | | 公開日 | 2015-07-22 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.797 Å) | | 主引用文献 | Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction.
Cell Death Dis, 6, 2015
|
|
4Z9V
 | | TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL | | 分子名称: | BICARBONATE ION, Bcl-2-like protein 1,APOPTOSIS REGULATOR BCL-XL, SODIUM ION, ... | | 著者 | Cura, V, Agez, M, Thebault, S, Cavarelli, J. | | 登録日 | 2015-04-12 | | 公開日 | 2016-02-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | | 主引用文献 | TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.
Sci Rep, 6, 2016
|
|
5AGW
 | | Bcl-2 alpha beta-1 complex | | 分子名称: | APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11 | | 著者 | Smith, B.J, F Lee, E, Checco, J.W, Gellman, S.H, Fairlie, W.D. | | 登録日 | 2015-02-04 | | 公開日 | 2015-09-09 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.695 Å) | | 主引用文献 | Alpha Beta Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity on Living Cells
J.Am.Chem.Soc., 137, 2015
|
|
4EHR
 | | Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide | | 分子名称: | 4-[5-butyl-3-(hydroxymethyl)-1-phenyl-1H-pyrazol-4-yl]-3-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}benzamide, Bcl-2-like protein 1, IMIDAZOLE | | 著者 | Schroeder, G.M, Wei, D, Banfi, P, Cai, Z, Lippy, J, Menichincheri, M, Modugno, M, Naglich, J, Penhallow, B, Perez, H.L, Sack, J, Schmidt, R.J, Tebben, A, Yan, C, Zhang, L, Galvani, A, Lombardo, L.J, Borzilleri, R.M. | | 登録日 | 2012-04-03 | | 公開日 | 2012-06-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.
Bioorg.Med.Chem.Lett., 22, 2012
|
|
4C52
 | | Crystal structure of Bcl-xL in complex with benzoylurea compound (39b) | | 分子名称: | (R)-2-(3-(3-((2,4-DIFLUOROPENYL)ETHYNYL)BENZOYL)-3-PROPYLUREIDO)-3-(ISOBUTYLTHIO) PROPANOIC ACID, 1,2-ETHANEDIOL, BCL-2-LIKE PROTEIN 1, ... | | 著者 | Roy, M.J, Brady, R.M, Lessene, G, Colman, P.M, Czabotar, P.E. | | 登録日 | 2013-09-10 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | | 主引用文献 | De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization.
J.Med.Chem., 57, 2014
|
|
4CIN
 | | Complex of Bcl-xL with its BH3 domain | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BCL-2-LIKE PROTEIN 1, ... | | 著者 | Colman, P.M, Lee, E.F, Fairlie, W.D. | | 登録日 | 2013-12-12 | | 公開日 | 2014-11-12 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.693 Å) | | 主引用文献 | The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
|
|
6RJP
 | | Bfl-1 in complex with alpha helical peptide | | 分子名称: | Bcl-2-like protein 11, Bcl-2-related protein A1 | | 著者 | Baggio, C, Gambini, L, Udompholkul, P, Salem, A.F, Hakansson, M, Jossart, J, Perry, J, Pellecchia, M. | | 登録日 | 2019-04-29 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists.
Chem.Biol.Drug Des., 95, 2020
|
|
6RNU
 | |
6ST2
 | | Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs | | 分子名称: | Affimer AF6, Bcl-2-like protein 1, SULFATE ION | | 著者 | Hobor, F, Miles, J.A, Trinh, C.H, Taylor, J, Tiede, C, Rowell, P.R, Jackson, B, Nadat, F, Kyle, H.F, Wicky, B.I.M, Clarke, J, Tomlinson, D.C, Wilson, A.J, Edwards, T.A. | | 登録日 | 2019-09-09 | | 公開日 | 2020-09-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Selective Affimers Recognise the BCL-2 Family Proteins BCL-x L and MCL-1 through Noncanonical Structural Motifs*.
Chembiochem, 22, 2021
|
|
6UA3
 | |
6TZC
 | | Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin | | 分子名称: | Apoptosis regulator Bcl-2 homolog, Beclin-1, Maltose/maltodextrin-binding periplasmic protein, ... | | 著者 | Banjara, S, Kvansakul, M, Hinds, M.G. | | 登録日 | 2019-08-12 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin.
Viruses, 11, 2019
|
|
6UAB
 | |
3INQ
 | | Crystal structure of BCL-XL in complex with W1191542 | | 分子名称: | 1,2-ETHANEDIOL, 4-[4-(biphenyl-3-ylmethyl)piperazin-1-yl]-N-{[4-({(1R)-3-(dimethylamino)-1-[(phenylsulfanyl)methyl]propyl}amino)-3-nitrophenyl]sulfonyl}benzamide, Bcl-2-like protein 1, ... | | 著者 | Fairlie, W.D, Smith, B.J, Colman, P.M, Czabotar, P.E, Lee, E.F. | | 登録日 | 2009-08-12 | | 公開日 | 2009-09-01 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands
J. Biol. Chem., 284, 2009
|
|
3IHC
 | |
3IIG
 | |
3IO8
 | | BimL12F in complex with Bcl-xL | | 分子名称: | Bcl-2-like protein 1, Bcl-2-like protein 11, ZINC ION | | 著者 | Colman, P.M, Lee, E.F, Fairlie, W.D, Smith, B.J, Czabotar, P.E, Yang, H, Sleebs, B.E, Lessene, G. | | 登録日 | 2009-08-14 | | 公開日 | 2009-09-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
|
|
3ILB
 | |
3IHD
 | |
3IO9
 | | BimL12Y in complex with Mcl-1 | | 分子名称: | Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION | | 著者 | Czabotar, P.E, Lee, E.F, Yang, H, Sleebs, B.E, Lessene, G, Colman, P.M, Smith, B.J, Fairlie, W.D. | | 登録日 | 2009-08-14 | | 公開日 | 2009-09-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
|
|
3IHF
 | |
3IIH
 | |
3IHE
 | |
3ILC
 | |
3KJ0
 | | Mcl-1 in complex with Bim BH3 mutant I2dY | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Fire, E, Grant, R.A, Keating, A.E. | | 登録日 | 2009-11-02 | | 公開日 | 2010-02-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Protein Sci., 19, 2010
|
|
3KJ1
 | | Mcl-1 in complex with Bim BH3 mutant I2dA | | 分子名称: | ACETATE ION, Bcl-2-like protein 11, CHLORIDE ION, ... | | 著者 | Fire, E, Grant, R.A, Keating, A.E. | | 登録日 | 2009-11-02 | | 公開日 | 2010-02-16 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.945 Å) | | 主引用文献 | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Protein Sci., 19, 2010
|
|
