6QG8

Structure of human Bcl-2 in complex with PUMA BH3 peptide

Summary for 6QG8

• Entry DOI: 10.2210/pdb6qg8/pdb
• Related: 6QFI 6qfm 6QGG 6QGH 6QGJ 6QGK
• Descriptor: Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1, Bcl-2-binding component 3 (3 entities in total)
• Functional Keywords: apoptosis, mcl1, bcl2, puma
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 23190.46

Authors

Dokurno, P.,Murray, J.,Davidson, J.,Chen, I.,Davis, B.,Graham, C.J.,Harris, R.,Jordan, A.M.,Matassova, N.,Pedder, C.,Ray, S.,Roughley, S.,Smith, J.,Walmsley, C.,Wang, Y.,Whitehead, N.,Williamson, D.S.,Casara, P.,Le Diguarher, T.,Hickman, J.,Stark, J.,Kotschy, A.,Geneste, O.,Hubbard, R.E. (deposition date: 2019-01-10, release date: 2019-06-12, Last modification date: 2024-01-24)

• Primary citation: Murray, J.B.,Davidson, J.,Chen, I.,Davis, B.,Dokurno, P.,Graham, C.J.,Harris, R.,Jordan, A.,Matassova, N.,Pedder, C.,Ray, S.,Roughley, S.D.,Smith, J.,Walmsley, C.,Wang, Y.,Whitehead, N.,Williamson, D.S.,Casara, P.,Le Diguarher, T.,Hickman, J.,Stark, J.,Kotschy, A.,Geneste, O.,Hubbard, R.E.; Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.; Acs Omega, 4:8892-8906, 2019; PubMed: 31459977; DOI: 10.1021/acsomega.9b00611

Experimental method

X-RAY DIFFRACTION (1.9 Å)