8EKX

Structure of MBP-Mcl-1 in complex with MIK665

Summary for 8EKX

Entry DOI	10.2210/pdb8ekx/pdb
Related PRD ID	PRD_900001
Descriptor	Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid, ... (4 entities in total)
Functional Keywords	mbp-mcl-1 fusion protein, apoptosis, mik665
Biological source	Escherichia coli K-12 More
Total number of polymer chains	1
Total formula weight	60354.58
Authors	Judge, R.A.,Judd, A.S.,Souers, A.J. (deposition date: 2022-09-22, release date: 2023-11-08)
Primary citation	Yuda, J.,Will, C.,Phillips, D.C.,Abraham, L.,Alvey, C.,Avigdor, A.,Buck, W.,Besenhofer, L.,Boghaert, E.,Cheng, D.,Cojocari, D.,Doyle, K.,Hansen, T.M.,Huang, K.,Johnson, E.F.,Judd, A.S.,Judge, R.A.,Kalvass, J.C.,Kunzer, A.,Lam, L.T.,Li, R.,Martin, R.L.,Mastracchio, A.,Mitten, M.,Petrich, A.,Wang, J.,Ward, J.E.,Zhang, H.,Wang, X.,Wolff, J.E.,Bell-McGuinn, K.M.,Souers, A.J. Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond), 3:154-154, 2023 Cited by PubMed: 37880389 DOI: 10.1038/s43856-023-00380-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation