8EKX
Structure of MBP-Mcl-1 in complex with MIK665
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 532 | 59136.9 | 1 | UniProt (P0AEX9) UniProt (Q07820) Pfam (PF01547) Pfam (PF00452) In PDB | Escherichia coli K-12 | |
2 | B | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | |||
3 | A | (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid | non-polymer | 875.4 | 1 | Chemie (OK5) | |||
4 | water | water | 18.0 | 550 | Chemie (HOH) |
Sequence modifications
A: -195 - 170 (UniProt: P0AEX9)
A: 173 - 321 (UniProt: Q07820)
PDB | External Database | Details |
---|---|---|
Met -210 | - | initiating methionine |
Ala -209 | - | expression tag |
His -208 | - | expression tag |
His -207 | - | expression tag |
His -206 | - | expression tag |
His -205 | - | expression tag |
His -204 | - | expression tag |
His -203 | - | expression tag |
Glu -202 | - | expression tag |
Asn -201 | - | expression tag |
Leu -200 | - | expression tag |
Tyr -199 | - | expression tag |
Phe -198 | - | expression tag |
Gln -197 | - | expression tag |
Gly -196 | - | expression tag |
Gly 171 | - | linker |
Ser 172 | - | linker |
PDB | External Database | Details |
---|---|---|
Ala 194 | Lys 194 | engineered mutation |
Ala 197 | Lys 197 | engineered mutation |
Ala 201 | Arg 201 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 59136.9 | |
Branched | Number of molecules | 1 |
Total formula weight | 342.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 875.4 | |
All* | Total formula weight | 60354.6 |