PDB: 1359 件ウェブページステータス検索Chemie searchBIRD

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7F68	Crystal structure of N-ras S89D 分子名称: GTPase NRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Li, Y, Sun, Q. 登録日 2021-06-24 公開日 2022-06-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Crystal structure of N-ras S89D To Be Published
7C7J	Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E) 分子名称: CALCIUM ION, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Xiao, L.X, Pan, L.F. 登録日 2020-05-25 公開日 2021-05-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Mechanistic Insights into the Interactions of Ras Subfamily GTPases with the SPN Domain of Autism-associated SHANK3. Chin.J.Chem., 38, 2020
7C7I	Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(E30D,K31E) 分子名称: CALCIUM ION, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Xiao, L.X, Pan, L.F. 登録日 2020-05-25 公開日 2021-05-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Mechanistic Insights into the Interactions of Ras Subfamily GTPases with the SPN Domain of Autism-associated SHANK3. Chin.J.Chem., 38, 2020
7C41	KRAS G12V and H-REV107 peptide complex 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, HRAS-like suppressor 3, ... 著者 Han, C.W, Jeong, M.S, Jang, S.B. 登録日 2020-05-14 公開日 2021-05-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.276 Å) 主引用文献 A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants. Cancers (Basel), 12, 2020
7C40	MgGDP bound KRAS G12V 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Han, C.W, Jeong, M.S, Jang, S.B. 登録日 2020-05-14 公開日 2021-05-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.516 Å) 主引用文献 A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants. Cancers (Basel), 12, 2020
7EQ2	Crystal structure of GDP-bound Rab1a-T75D 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, COBALT HEXAMMINE(III), ... 著者 Cao, Y.L, Gu, D.D, Gao, S. 登録日 2021-04-28 公開日 2022-11-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.55090284 Å) 主引用文献 Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis Nat.Struct.Mol.Biol., 2024
6O46	Crystal structure of human KRAS P34R mutant in complex with GNP and Phosphate 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Bera, A.K, Westover, K.D. 登録日 2019-02-28 公開日 2020-03-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R. Birth Defects Res, 112, 2020
2P5S	RAB domain of human RASEF in complex with GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, RAS and EF-hand domain containing, UNKNOWN ATOM OR ION 著者 Zhu, H, Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2007-03-16 公開日 2007-03-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 RAB domain of human RASEF in complex with GDP To be Published
6OIM	Crystal Structure of human KRAS G12C covalently bound to AMG 510 分子名称: AMG 510 (bound form), GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Mohr, C. 登録日 2019-04-09 公開日 2019-11-06 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature, 575, 2019
6O62	Crystal structure of Sec4p, a Rab family GTPase from Candida albicans 分子名称: GUANOSINE-5'-DIPHOSPHATE, Ras-related protein SEC4 著者 Stogios, P.J, Skarina, T, Di Leo, R, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2019-03-05 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 To be published To Be Published
2QRZ	Cdc42 bound to GMP-PCP: Induced Fit by Effector is Required 分子名称: Cell division control protein 42 homolog precursor, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... 著者 Phillips, M.J, Calero, G, Chan, B, Cerione, R.A. 登録日 2007-07-30 公開日 2008-03-18 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42. J.Biol.Chem., 283, 2008
2QUZ	Crystal Structure of the activating H-RasK117R mutant in Costello Syndrome, bound to Mg-GDP 分子名称: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Parret, A, Scheffzek, K. 登録日 2007-08-07 公開日 2007-12-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation. Hum.Mutat., 29, 2008
6P0K	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. 分子名称: 4-[(6-chloropyridin-2-yl)sulfamoyl]benzene-1-sulfonic acid, CALCIUM ION, CHLORIDE ION, ... 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0O	Crystal structure of GDP-bound human RalA 分子名称: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Ral-A 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0N	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. 分子名称: 4-[(6-fluoropyridin-2-yl)sulfamoyl]benzene-1-sulfonic acid, CALCIUM ION, CHLORIDE ION, ... 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0Z	Crystal structure of N-acetylated KRAS (2-169) bound to GDP and Mg 分子名称: ACETYL GROUP, DI(HYDROXYETHYL)ETHER, GTPase KRas, ... 著者 Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. 登録日 2019-05-17 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.011 Å) 主引用文献 Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
6P8Z	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor 分子名称: 2-[5-chloro-2-cyclopropyl-3-(5-methoxy-3,4-dihydroisoquinoline-2(1H)-carbonyl)-7-methyl-1H-indol-1-yl]-N-(1-propanoylazetidin-3-yl)acetamide, CALCIUM ION, GTPase KRas, ... 著者 Mohr, C. 登録日 2019-06-08 公開日 2019-08-28 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019
2RAP	THE SMALL G PROTEIN RAP2A IN COMPLEX WITH GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RAP2A 著者 Cherfils, J, Menetrey, J, Lebras, G. 登録日 1998-05-06 公開日 1998-06-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS. EMBO J., 16, 1997
6P0M	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. 分子名称: 4-[(3-chloropyridin-2-yl)sulfamoyl]benzene-1-sulfonic acid, CALCIUM ION, CHLORIDE ION, ... 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0J	Crystal structure of GDP-bound human RalA 分子名称: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Ral-A 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6PGO	Crystal structure of human KRAS G12C covalently bound to a phthalazine inhibitor 分子名称: 1-{4-[7-chloro-6-(2-fluoro-6-hydroxyphenyl)-4-phenylphthalazin-1-yl]piperazin-1-yl}propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Mohr, C. 登録日 2019-06-24 公開日 2019-12-25 最終更新日 2020-01-22 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of a Covalent Inhibitor of KRASG12C(AMG 510) for the Treatment of Solid Tumors. J.Med.Chem., 63, 2020
2P2L	Rac1-GDP-Zinc Complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, Ras-related C3 botulinum toxin substrate 1, ZINC ION 著者 Prehna, G, Stebbins, C.E. 登録日 2007-03-07 公開日 2007-05-01 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A Rac1-GDP trimer complex binds zinc with tetrahedral and octahedral coordination, displacing magnesium. Acta Crystallogr.,Sect.D, 63, 2007
6P0I	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. 分子名称: 1,2-ETHANEDIOL, 4-[(5-methoxypyridin-3-yl)sulfamoyl]benzene-1-sulfonic acid, ACETATE ION, ... 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0L	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. 分子名称: 4-[(2-methoxypyridin-3-yl)sulfamoyl]benzene-1-sulfonic acid, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P8W	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor. 分子名称: CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Mohr, C. 登録日 2019-06-08 公開日 2019-08-28 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019

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