2QUZ

Crystal Structure of the activating H-RasK117R mutant in Costello Syndrome, bound to Mg-GDP

Summary for 2QUZ

Entry DOI	10.2210/pdb2quz/pdb
Descriptor	GTPase HRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	hydrolase, gtpase protein, costello syndrome, ras protein, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side: P01112
Total number of polymer chains	1
Total formula weight	19370.71
Authors	Parret, A.,Scheffzek, K. (deposition date: 2007-08-07, release date: 2007-12-11, Last modification date: 2023-08-30)
Primary citation	Denayer, E.,Parret, A.,Chmara, M.,Schubbert, S.,Vogels, A.,Devriendt, K.,Frijns, J.P.,Rybin, V.,de Ravel, T.J.,Shannon, K.,Cools, J.,Scheffzek, K.,Legius, E. Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation. Hum.Mutat., 29:232-239, 2008 Cited by PubMed: 17979197 DOI: 10.1002/humu.20616 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49 Å)

Structure validation