2QUZ
Crystal Structure of the activating H-RasK117R mutant in Costello Syndrome, bound to Mg-GDP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTPase HRas | polymer | 166 | 18903.2 | 1 | UniProt (P01112) Pfam (PF00071) | Homo sapiens (human) | C-H-RAS P21 PROTEIN; Transforming protein p21; p21ras; H-Ras-1; c-H-ras; Ha-Ras |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 3 | C (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 4 | D (A) | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A: 1 - 166 (UniProt: P01112)
| PDB | External Database | Details |
|---|---|---|
| Arg 117 | Lys 117 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18903.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 467.5 | |
| All* | Total formula weight | 19370.7 |
