4U17
| Swapped dimer of the human Fyn-SH2 domain | 分子名称: | 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn | 著者 | Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. | 登録日 | 2014-07-15 | 公開日 | 2015-07-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Swapped dimer of the human Fyn-SH2 domain To Be Published
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4U1P
| Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide | 分子名称: | Middle T antigen, POLYETHYLENE GLYCOL (N=34), SODIUM ION, ... | 著者 | Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. | 登録日 | 2014-07-16 | 公開日 | 2015-07-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide To Be Published
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4U5W
| Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Protein Nef, ... | 著者 | Alvarado, J.J, Yeh, J.I, Smithgall, T.E. | 登録日 | 2014-07-25 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment. J.Biol.Chem., 289, 2014
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4WAF
| Crystal Structure of a novel tetrahydropyrazolo[1,5-a]pyrazine in an engineered PI3K alpha | 分子名称: | N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Knapp, M.S, Elling, R.A. | 登録日 | 2014-08-29 | 公開日 | 2014-12-31 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR Inhibitors. Acs Med.Chem.Lett., 6, 2015
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4ROJ
| Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide | 分子名称: | Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION | 著者 | Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2014-10-28 | 公開日 | 2014-12-10 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide TO BE PUBLISHED
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4WWQ
| Apo structure of the Grb7 SH2 domain | 分子名称: | Growth factor receptor-bound protein 7, MALONIC ACID | 著者 | Watson, G.M, Ambaye, N.D, Wilce, M.C, Wilce, J.A. | 登録日 | 2014-11-12 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
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4X6S
| Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide | 分子名称: | Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1 | 著者 | Watson, G.M, Panjikar, S, Wilce, M.C, Wilce, J.A. | 登録日 | 2014-12-09 | 公開日 | 2015-09-23 | 最終更新日 | 2015-10-28 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
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4XEY
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4XI2
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4XZ1
| ZAP-70-tSH2:Compound-B adduct | 分子名称: | 2-[(7-chloro-4-nitro-2,1,3-benzoxadiazol-5-yl)amino]ethanol, Tyrosine-protein kinase ZAP-70, doubly phosphorylated ITAM peptide | 著者 | Barros, T, Kuriyan, J, Winger, J.A, Visperas, P.R. | 登録日 | 2015-02-03 | 公開日 | 2015-07-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem. J., 465, 2015
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4XZ0
| ZAP-70-tSH2:compound-A complex | 分子名称: | 1-(3-{5-[(3-chlorobenzyl)sulfonyl]-1H-tetrazol-1-yl}phenyl)ethanone, SULFATE ION, Tyrosine-protein kinase ZAP-70 | 著者 | Barros, T, Kuriyan, J, Visperas, P.R, Winger, J.A. | 登録日 | 2015-02-03 | 公開日 | 2015-06-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem. J., 465, 2015
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4Y5U
| Transcription factor | 分子名称: | NICKEL (II) ION, Signal transducer and activator of transcription 6 | 著者 | Li, J, Niu, F, Ouyang, S, Liu, Z. | 登録日 | 2015-02-12 | 公開日 | 2016-02-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.708 Å) | 主引用文献 | Structural basis for DNA recognition by STAT6 Proc.Natl.Acad.Sci.USA, 113, 2016
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4Y5W
| Transcription factor-DNA complex | 分子名称: | DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*GP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*CP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3'), Signal transducer and activator of transcription 6 | 著者 | Li, J, Niu, F, Ouyang, S, Liu, Z. | 登録日 | 2015-02-12 | 公開日 | 2016-02-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.104 Å) | 主引用文献 | Structural basis for DNA recognition by STAT6 Proc.Natl.Acad.Sci.USA, 113, 2016
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4YKN
| Pi3K alpha lipid kinase with Active Site Inhibitor | 分子名称: | 3-(6-methoxypyridin-3-yl)-5-[({4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}amino)methyl]benzoic acid, Phosphatidylinositol 3-kinase regulatory subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform fusion protein | 著者 | Elkins, P.A. | 登録日 | 2015-03-04 | 公開日 | 2015-06-17 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Discovery of a Potent Class of PI3K alpha Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT). Acs Med.Chem.Lett., 6, 2015
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4Z32
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5AUL
| PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex | 分子名称: | GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, T-cell-specific surface glycoprotein CD28 | 著者 | Inaba, S, Numoto, N, Morii, H, Ikura, T, Oda, M, Ito, N. | 登録日 | 2015-04-28 | 公開日 | 2016-05-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
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4ZOP
| Co-crystal Structure of Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor | 分子名称: | (2S,3R)-N~1~-(8-tert-butyl-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl)-3-methylpyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Knapp, M.S, Elling, R.A. | 登録日 | 2015-05-06 | 公開日 | 2016-05-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Co-crystal Structure of the Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitorCo-crystal Structure of the Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor To Be Published
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5BO4
| Structure of SOCS2:Elongin C:Elongin B from DMSO-treated crystals | 分子名称: | Suppressor of cytokine signaling 2, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2 | 著者 | Gadd, M.S, Bulatov, E, Ciulli, A. | 登録日 | 2015-05-27 | 公開日 | 2015-07-08 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases. Plos One, 10, 2015
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5CDW
| Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide | 分子名称: | Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN | 著者 | Papaioannou, D, Geibel, S, Kunze, M, Kay, C, Waksman, G. | 登録日 | 2015-07-05 | 公開日 | 2016-05-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | 主引用文献 | Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. Protein Sci., 25, 2016
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5D0J
| Grb7 SH2 with inhibitor peptide | 分子名称: | G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION | 著者 | Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J. | 登録日 | 2015-08-03 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
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5D39
| Transcription factor-DNA complex | 分子名称: | DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*GP*GP*AP*AP*GP*AP*CP*AP*GP*A)-3'), DNA (5'-D(P*TP*CP*TP*GP*TP*CP*TP*TP*CP*CP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3'), Signal transducer and activator of transcription 6 | 著者 | Li, J, Niu, F, Ouyang, S, Liu, Z. | 登録日 | 2015-08-06 | 公開日 | 2016-08-10 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for DNA recognition by STAT6 Proc.Natl.Acad.Sci.USA, 113, 2016
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5DC0
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5DC9
| CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL B | 分子名称: | AS25 monobody, GLYCEROL, IMIDAZOLE, ... | 著者 | Wojcik, J.B, Koide, A, Koide, S. | 登録日 | 2015-08-23 | 公開日 | 2016-03-02 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface. J.Biol.Chem., 291, 2016
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5DC4
| CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL A | 分子名称: | AS25 monobody, GLYCEROL, Tyrosine-protein kinase ABL1 | 著者 | Wojcik, J.B, Koide, A, Koide, S. | 登録日 | 2015-08-23 | 公開日 | 2016-03-02 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface. J.Biol.Chem., 291, 2016
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5DF6
| Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11, UNKNOWN ATOM OR ION, txnip | 著者 | Dong, A, Li, W, Tempel, W, Liu, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2015-08-26 | 公開日 | 2015-09-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem.J., 473, 2016
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