PDB: 46188 件ウェブページステータス検索Chemie searchBIRD

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5FMQ	Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza A virus polymerase PB2 subunit bound to M7GTP H32 crystal form 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, INFLUENZA A PB2 SUBUNIT 著者 Thierry, E, Pflug, A, Hart, D, Cusack, S. 登録日 2015-11-07 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016
2X0L	Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase LSD1. 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, HISTONE H3 PEPTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... 著者 Zibetti, C, Adamo, A, Binda, C, Forneris, F, Verpelli, C, Ginelli, E, Mattevi, A, Sala, C, Battaglioli, E. 登録日 2009-12-15 公開日 2010-03-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Alternative Splicing of the Histone Demethylase Lsd1/Kdm1 Contributes to the Modulation of Neurite Morphogenesis in the Mammalian Nervous System. J.Neurosci., 30, 2010
6S9X	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 15c 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-[(4-hydroxyphenyl)methyl]-6-oxidanylidene-2-phenyl-1~{H}-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2019-07-15 公開日 2019-10-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. Angew.Chem.Int.Ed.Engl., 58, 2019
3RUU	FXR with SRC1 and GSK237 分子名称: 6-(4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)-1H-indole-3-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1, ... 著者 Williams, S.P, Madauss, K.P. 登録日 2011-05-05 公開日 2011-09-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene. Bioorg.Med.Chem.Lett., 21, 2011
2WXZ	Crystal structure of rat angiotensinogen in C2 space group 分子名称: ANGIOTENSINOGEN 著者 Zhou, A, Wei, Z, Carrell, R.W, Read, R.J. 登録日 2009-11-11 公開日 2010-10-20 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A Redox Switch in Angiotensinogen Modulates Angiotensin Release. Nature, 468, 2010
4R25	Structure of B. subtilis GlnK 分子名称: Nitrogen regulatory PII-like protein, ZINC ION 著者 Schumacher, M.A. 登録日 2014-08-08 公開日 2015-03-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5193 Å) 主引用文献 Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis. Genes Dev., 29, 2015
5ED3	crystal structure of human Hint1 complexing with AP5A 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1 著者 Wang, J, Fang, P, Guo, M. 登録日 2015-10-20 公開日 2017-01-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.309 Å) 主引用文献 Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells. Nat Commun, 10, 2019
5EDB	human fatty acid binding protein 4 in complex with 6-Chloro-2-methyl-4-phenyl-quinoline-3-carboxylic acid at 1.18A 分子名称: 6-chloranyl-2-methyl-4-phenyl-quinoline-3-carboxylic acid, Fatty acid-binding protein, adipocyte 著者 Rudolph, M.G, Ehler, A. 登録日 2015-10-21 公開日 2016-03-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 A Real-World Perspective on Molecular Design. J.Med.Chem., 59, 2016
8ODR	Mimetic of UBC9-SUMO1 分子名称: SULFATE ION, SUMO-conjugating enzyme UBC9, Small ubiquitin-related modifier 1 著者 Coste, F, Goffinont, S, Suskiewicz, M.J. 登録日 2023-03-09 公開日 2023-06-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its stable mimetic. J.Biol.Chem., 299, 2023
3SP9	Structural basis for iloprost as a dual PPARalpha/delta agonist 分子名称: (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid, Peroxisome proliferator-activated receptor delta 著者 Rong, H, Li, Y. 登録日 2011-07-01 公開日 2011-07-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist. J.Biol.Chem., 286, 2011
4Z2B	The structure of human PDE12 residues 161-609 in complex with GSK3036342A 分子名称: 1,2-ETHANEDIOL, 2',5'-phosphodiesterase 12, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... 著者 Nolte, R.T, Wisely, B, Wang, L, Wood, E.R. 登録日 2015-03-29 公開日 2015-06-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. J.Biol.Chem., 290, 2015
8DKB	Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b 分子名称: N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide, YEATS domain-containing protein 4 著者 Dias, J.M, Byrnes, L.J, Varghese, A.H. 登録日 2022-07-05 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4. J.Med.Chem., 66, 2023
6SIT	Pseudo-atomic crystal structure of the desmoglein 2 - human adenovirus serotype 3 fibre knob complex 分子名称: CALCIUM ION, Desmoglein-2, Fiber protein 著者 Burmeister, W.P, Fender, P, Vassal-Stermann, E. 登録日 2019-08-11 公開日 2019-12-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Intermediate-resolution crystal structure of the human adenovirus B serotype 3 fibre knob in complex with the EC2-EC3 fragment of desmoglein 2. Acta Crystallogr.,Sect.F, 75, 2019
3SZ1	Human PPAR gamma ligand binding domain in complex with luteolin and myristic acid 分子名称: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, MYRISTIC ACID, Peroxisome proliferator-activated receptor gamma, ... 著者 Puhl, A.C, Bernardes, A, Polikarpov, I. 登録日 2011-07-18 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mode of peroxisome proliferator-activated receptor gamma activation by luteolin. Mol.Pharmacol., 81, 2012
5EP0	Quorum-Sensing Signal Integrator LuxO - Receiver+Catalytic Domains 分子名称: 1,2-ETHANEDIOL, Putative repressor protein luxO, SULFATE ION 著者 Shah, T, Selcuk, H.B, Jeffrey, P.D, Hughson, F.M. 登録日 2015-11-11 公開日 2016-04-20 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO. Plos Biol., 14, 2016
6X61	Crystal structure of the N-terminal thioredoxin domain of SasA in complex with the N-terminal CI domain of KaiC from Thermosynchococcus elongatus 分子名称: Adaptive-response sensory-kinase SasA, Circadian clock protein kinase KaiC, PHOSPHATE ION 著者 Swan, J.A, Tripathi, S.M, Partch, C.L. 登録日 2020-05-27 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Reconstitution of an intact clock reveals mechanisms of circadian timekeeping. Science, 374, 2021
6S9T	Dimerization domain of Xenopus laevis LDB1 in complex with darpin 3 分子名称: Darpin 3, LIM domain-binding protein 1, TETRAETHYLENE GLYCOL 著者 Renko, M, Schaefer, J.V, Pluckthun, A, Bienz, M. 登録日 2019-07-15 公開日 2019-10-09 最終更新日 2019-10-23 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome. Proc.Natl.Acad.Sci.USA, 116, 2019
5EIC	Crystal structure of the bromodomain of human CREBBP in complex with AYC 分子名称: 1,2-ETHANEDIOL, 2-[(chloroacetyl)amino]-5-[(E)-(4-sulfophenyl)diazenyl]benzenesulfonic acid, CREB-binding protein 著者 Dong, J, Caflisch, A. 登録日 2015-10-29 公開日 2016-11-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9, 2018
3E1K	Crystal structure of Kluyveromyces lactis Gal80p in complex with the acidic activation domain of Gal4p 分子名称: Galactose/lactose metabolism regulatory protein GAL80, Lactose regulatory protein LAC9 著者 Thoden, J.B, Holden, H.M. 登録日 2008-08-04 公開日 2008-08-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The Interaction between an Acidic Transcriptional Activator and Its Inhibitor: THE MOLECULAR BASIS OF Gal4p RECOGNITION BY Gal80p. J.Biol.Chem., 283, 2008
5F8I	Enterovirus 71 Polymerase Elongation Complex (C1S2/3 Form) 分子名称: CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, Genome polyprotein, ... 著者 Shu, B, Gong, P. 登録日 2015-12-09 公開日 2016-06-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.503 Å) 主引用文献 Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Proc.Natl.Acad.Sci.USA, 113, 2016
6XT9	Subunits BBS 1,4,8,9,18 of the human BBSome complex 分子名称: BBSome-interacting protein 1, Bardet-Biedl syndrome 1 protein, Bardet-Biedl syndrome 4 protein, ... 著者 Klink, B.U, Raunser, S, Gatsogiannis, C. 登録日 2020-01-15 公開日 2020-01-29 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structure of the human BBSome core complex. Elife, 9, 2020
2WK4	Dimeric structure of D347G D348G mutant of the sapporovirus RNA dependent RNA polymerase 分子名称: GLYCEROL, PROTEASE-POLYMERASE P70 著者 Fullerton, S.W.B, Robel, I, Schuldt, L, Gebhardt, J, Tucker, P.A, Rohayem, J. 登録日 2009-06-05 公開日 2010-09-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Dimeric Structure of D347G D348G Mutant of the Sapporovirus Sapporovirus RNA Dependent RNA Polymerase To be Published
4ZDR	Crystal structure of 14-3-3[zeta]-LKB1 fusion protein 分子名称: 14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11, GLYCEROL, PROPANE, ... 著者 Ding, S, Shi, Z.B. 登録日 2015-04-18 公開日 2015-09-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.899 Å) 主引用文献 Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3. Acta Crystallogr.,Sect.F, 71, 2015
6O6X	Crystal structure of Csm6 W14A/E337A mutant in complex with cA4 by cocrystallization 分子名称: Csm6, Cyclic RNA cA4 著者 Jia, N, Patel, D.J. 登録日 2019-03-07 公開日 2019-07-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity. Mol.Cell, 75, 2019
6S9S	Dimerization domain of Xenopus laevis LDB1 in complex with darpin 10 分子名称: Darpin 10, LIM domain-binding protein 1 著者 Renko, M, Schaefer, J.V, Pluckthun, A, Bienz, M. 登録日 2019-07-15 公開日 2019-10-09 最終更新日 2019-10-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome. Proc.Natl.Acad.Sci.USA, 116, 2019

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