3SZ1

Human PPAR gamma ligand binding domain in complex with luteolin and myristic acid

Summary for 3SZ1

Related3OM9 1PRG 3PBA
DescriptorPeroxisome proliferator-activated receptor gamma, nonanoic acid, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, ... (5 entities in total)
Functional Keywordsppar gamma, nuclear receptor, luteolin, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight64300.81
Authors
Puhl, A.C.,Bernardes, A.,Polikarpov, I. (deposition date: 2011-07-18, release date: 2012-03-21, Last modification date: 2013-06-19)
Primary citation
Puhl, A.C.,Bernardes, A.,Silveira, R.L.,Yuan, J.,Campos, J.L.,Saidemberg, D.M.,Palma, M.S.,Cvoro, A.,Ayers, S.D.,Webb, P.,Reinach, P.S.,Skaf, M.S.,Polikarpov, I.
Mode of peroxisome proliferator-activated receptor gamma activation by luteolin.
Mol.Pharmacol., 81:788-799, 2012
PubMed: 22391103 (PDB entries with the same primary citation)
DOI: 10.1124/mol.111.076216
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.239501.1%4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report