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3SZ1

Human PPAR gamma ligand binding domain in complex with luteolin and myristic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE KNA A 1
ChainResidue
AGLU259
AILE281
AGLY284
AARG288
AILE341
ASER342

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE KNA A 2
ChainResidue
AALA292
AGLU295
AILE326
AMET329
ALEU330
ACYS285
AARG288
ASER289

site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE LU2 B 1
ChainResidue
BHOH15
BHOH94
BPHE264
BLYS265
BHIS266
BGLY284
BCYS285
BPHE287
BARG288
BLEU330
BMET364
BMYR478

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE MYR B 478
ChainResidue
BLU21
BHOH94
BARG288
BSER289
BLEU333
BPHE363
BMET364
BHIS449

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
AGLN286
AHIS323
AHIS449
ATYR473
BGLN286
BHIS323
BHIS449
BTYR473

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
ALYS224
BLYS224

226707

PDB entries from 2024-10-30

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