5ED3

crystal structure of human Hint1 complexing with AP5A

Summary for 5ED3

Entry DOI	10.2210/pdb5ed3/pdb
Related	5ECB 5ECZ 5ED5 5ED6 5EDE 5EFL 5EFP
Descriptor	Histidine triad nucleotide-binding protein 1, ADENOSINE MONOPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	hydrolase, nucleotide binding, regulation of transcription, signal transduction
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	28633.86
Authors	Wang, J.,Fang, P.,Guo, M. (deposition date: 2015-10-20, release date: 2017-01-25, Last modification date: 2023-09-27)
Primary citation	Yu, J.,Liu, Z.,Liang, Y.,Luo, F.,Zhang, J.,Tian, C.,Motzik, A.,Zheng, M.,Kang, J.,Zhong, G.,Liu, C.,Fang, P.,Guo, M.,Razin, E.,Wang, J. Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells. Nat Commun, 10:4664-4664, 2019 Cited by PubMed: 31604935 DOI: 10.1038/s41467-019-12710-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.309 Å)

Structure validation