8ATX
 
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8ATU
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8AUW
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8AUK
 | | Cryo-EM structure of human BIRC6 in complex with HTRA2. | | 分子名称: | Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial, ... | | 著者 | Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. | | 登録日 | 2022-08-25 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | | 主引用文献 | Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Science, 379, 2023
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8AMS
 | | Complex of human TRIM2 RING domain, UBCH5C, and Ubiquitin | | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, Polyubiquitin-C, ... | | 著者 | Perez-Borrajero, C, Kotova, I, Murciano, B, Hennig, J. | | 登録日 | 2022-08-04 | | 公開日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and biophysical studies of TRIM2 and TRIM3
To Be Published
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8ATM
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8ATO
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2GRR
 | | Crystal Structure of human RanGAP1-Ubc9-D127S | | 分子名称: | Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I | | 著者 | Yunus, A.A, Lima, C.D. | | 登録日 | 2006-04-24 | | 公開日 | 2006-05-30 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
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8B3I
 | | CRL4CSA-E2-Ub (state 2) | | 分子名称: | Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ... | | 著者 | Kokic, G, Cramer, P. | | 登録日 | 2022-09-16 | | 公開日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | C(N)RL4CSA-E2-Ub (state 2)
To Be Published
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8BTL
 | | Crystal structure of a complex between the E2 conjugating enzyme UBE2A and the E3 ligase module from UBR4 | | 分子名称: | Ubiquitin conjugating enzyme E2 A, ZINC ION, cDNA FLJ12511 fis, ... | | 著者 | Virdee, S, Mabbitt, P.D, Barnsby-Greer, L. | | 登録日 | 2022-11-29 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4.
Nat.Struct.Mol.Biol., 31, 2024
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2GRP
 | | Crystal Structure of human RanGAP1-Ubc9-Y87A | | 分子名称: | Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I | | 著者 | Yunus, A.A, Lima, C.D. | | 登録日 | 2006-04-24 | | 公開日 | 2006-05-30 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
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2GMI
 | | Mms2/Ubc13~Ubiquitin | | 分子名称: | Ubiquitin, Ubiquitin-conjugating enzyme E2 13, Ubiquitin-conjugating enzyme variant MMS2 | | 著者 | Wolberger, C, Eddins, M.J, Carlile, C.M, Gomez, K.G, Pickart, C.M. | | 登録日 | 2006-04-06 | | 公開日 | 2006-09-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation.
Nat.Struct.Mol.Biol., 13, 2006
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2GRO
 | | Crystal Structure of human RanGAP1-Ubc9-N85Q | | 分子名称: | Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I | | 著者 | Yunus, A.A, Lima, C.D. | | 登録日 | 2006-04-24 | | 公開日 | 2006-05-30 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
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2GRN
 | | Crystal Structure of human RanGAP1-Ubc9 | | 分子名称: | Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I | | 著者 | Yunus, A.A, Lima, C.D. | | 登録日 | 2006-04-24 | | 公開日 | 2006-05-30 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
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2GRQ
 | | Crystal Structure of human RanGAP1-Ubc9-D127A | | 分子名称: | Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I | | 著者 | Yunus, A.A, Lima, C.D. | | 登録日 | 2006-04-24 | | 公開日 | 2006-05-30 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
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2KJH
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8J1R
 | | cryo-EM structures of Ufd4 in complex with Ubc4-Ub | | 分子名称: | Ubiquitin fusion degradation protein 4, Ubiquitin-conjugating enzyme E2 4 | | 著者 | Ai, H.S, Mao, J.X, Wu, X.W, Cai, H.Y, Pan, M, Liu, L. | | 登録日 | 2023-04-13 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Structural Visualization of HECT-E3 Ufd4 accepting and transferring Ubiquitin to Form K29/K48-branched Polyubiquitination on N-degron. bioRxiv,doi: ttps://doi.org/10.1101/2023.05.23.542033
To Be Published
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8ODR
 | | Mimetic of UBC9-SUMO1 | | 分子名称: | SULFATE ION, SUMO-conjugating enzyme UBC9, Small ubiquitin-related modifier 1 | | 著者 | Coste, F, Goffinont, S, Suskiewicz, M.J. | | 登録日 | 2023-03-09 | | 公開日 | 2023-06-07 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its stable mimetic.
J.Biol.Chem., 299, 2023
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8JWJ
 | | PHD Finger Protein 7 (PHF7) in complex with UBE2D2 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, PHD finger protein 7, ... | | 著者 | Lee, H.S, Bang, I, Choi, H.-J. | | 登録日 | 2023-06-29 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | | 主引用文献 | Molecular basis for PHF7-mediated ubiquitination of histone H3.
Genes Dev., 37, 2023
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8JWU
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8PJN
 | | Catalytic module of human CTLH E3 ligase bound to multiphosphorylated UBE2H~ubiquitin | | 分子名称: | E3 ubiquitin-protein transferase MAEA, E3 ubiquitin-protein transferase RMND5A, Ubiquitin, ... | | 著者 | Chrustowicz, J, Sherpa, D, Prabu, R.J, Schulman, B.A. | | 登録日 | 2023-06-23 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.
Mol.Cell, 84, 2024
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8PMQ
 | | Catalytic module of yeast GID E3 ligase bound to multiphosphorylated Ubc8~ubiquitin | | 分子名称: | E3 ubiquitin-protein ligase RMD5, Protein FYV10, Ubiquitin, ... | | 著者 | Chrustowicz, J, Sherpa, D, Prabu, R.J, Schulman, B.A. | | 登録日 | 2023-06-29 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.
Mol.Cell, 84, 2024
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8PQL
 | | K48-linked ubiquitin chain formation with a cullin-RING E3 ligase and Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2-donor UB-acceptor UB-SIL1 peptide | | 分子名称: | 5-azanylpentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | | 登録日 | 2023-07-11 | | 公開日 | 2024-02-14 | | 最終更新日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | | 主引用文献 | Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases.
Nat.Struct.Mol.Biol., 31, 2024
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8OIF
 | | Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6 | | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | | 著者 | Wallace, I, Kheewoong, B, Prabu, J.R, Vollrath, R, von Gronau, S, Schulman, B.A, Swatek, K.N. | | 登録日 | 2023-03-22 | | 公開日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Insights into the ISG15 transfer cascade by the UBE1L activating enzyme.
Nat Commun, 14, 2023
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8Q7R
 | | Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide | | 分子名称: | 5-azanyl-1-oxidanyl-pentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | | 登録日 | 2023-08-16 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Mol.Cell, 84, 2024
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