PDB: 501 件ウェブページステータス検索Chemie searchBIRD

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4KF6	Crystal structure of human ceramide-1-phosphate transfer protein (CPTP) in complex with 8:0 Ceramide-1-Phosphate (8:0-C1P) 分子名称: (2S,3R,4E)-3-hydroxy-2-(octanoylamino)octadec-4-en-1-yl dihydrogen phosphate, Glycolipid transfer protein domain-containing protein 1 著者 Simanshu, D.K, Brown, R.E, Patel, D.J. 登録日 2013-04-26 公開日 2013-07-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.195 Å) 主引用文献 Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. Nature, 500, 2013
4W5Q	The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2014-08-18 公開日 2014-11-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.101 Å) 主引用文献 Gene regulation. Structural basis for microRNA targeting. Science, 346, 2014
7KI3	Human Argonaute2:miR-122 bound to the HCV genotype 1a site-1 RNA 分子名称: BARIUM ION, HCV genotype 1a miR-122 site-1, Protein argonaute-2, ... 著者 Gebert, L.F.R, MacRae, I.J. 登録日 2020-10-22 公開日 2021-10-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A structured RNA motif locks Argonaute2:miR-122 onto the 5' end of the HCV genome. Nat Commun, 12, 2021
2Q1O	Crystal Structure Analysis of the RNA Dodecamer CGC-NF2-AAUUGGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2) 分子名称: RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3') 著者 Li, F, Pallan, P.S. 登録日 2007-05-25 公開日 2007-10-30 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. Nucleic Acids Res., 35, 2007
2Q1R	Crystal Structure Analysis of the RNA Dodecamer CGCGAAUUAGCG, with a G-A mismatch. 分子名称: MAGNESIUM ION, RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3') 著者 Li, F, Pallan, P.S. 登録日 2007-05-25 公開日 2007-10-30 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. Nucleic Acids Res., 35, 2007
7ROZ	Structure of RNA-dependent RNA polymerase 2 (RDR2) from Arabidopsis thaliana 分子名称: MAGNESIUM ION, RNA-dependent RNA polymerase 2 著者 Fukudome, A, Pikaard, C.S, Takagi, Y. 登録日 2021-08-02 公開日 2021-12-08 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2. Proc.Natl.Acad.Sci.USA, 118, 2021
7RQS	Arabidopsis RNA-dependent RNA polymerase 2 分子名称: MAGNESIUM ION, RNA-dependent RNA polymerase 2 著者 Fukudome, A, Pikaard, C.S, Takagi, Y. 登録日 2021-08-07 公開日 2021-12-08 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2. Proc.Natl.Acad.Sci.USA, 118, 2021
4W5R	The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 (Long Target) 分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2014-08-18 公開日 2014-11-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Gene regulation. Structural basis for microRNA targeting. Science, 346, 2014
4W5N	The Crystal Structure of Human Argonaute2 Bound to a Defined Guide RNA 分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... 著者 Schirle, N.T, Sheu-Gruttadauria, J, MacRae, I.J. 登録日 2014-08-18 公開日 2014-11-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Gene regulation. Structural basis for microRNA targeting. Science, 346, 2014
4W5O	The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-9 分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2014-08-18 公開日 2014-11-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.802 Å) 主引用文献 Gene regulation. Structural basis for microRNA targeting. Science, 346, 2014
4W5T	The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-7 分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2014-08-18 公開日 2014-11-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Gene regulation. Structural basis for microRNA targeting. Science, 346, 2014
5T7B	Argonaute-2 - 5'-(E)-vinylphosphonate 2'-O-methyl-uridine modified mrTTR guide RNA complex 分子名称: PHENOL, Protein argonaute-2, RNA (UVP)UAUAGAGCAAGAACACUGUU 著者 Elkayam, E, Joshua-Tor, L. 登録日 2016-09-02 公開日 2016-12-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.529 Å) 主引用文献 Protein structure To Be Published
5THE	Crystal structure of the C-terminal lobe of a budding yeast Argonaute 分子名称: RNA (5'-R(P*UP*AP*AP*AP*AP*AP*AP*A)-3'), Uncharacterized protein 著者 Dayeh, D.M, Nakanishi, K. 登録日 2016-09-29 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.097 Å) 主引用文献 Structural and functional analyses reveal the contributions of the C- and N-lobes of Argonaute protein to selectivity of RNA target cleavage. J. Biol. Chem., 293, 2018
8HYJ	A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex 分子名称: DNA (48-MER), DNA-directed RNA polymerase V subunit 1, DNA-directed RNA polymerase V subunit 5A, ... 著者 Zhang, H, Zhang, Y. 登録日 2023-01-06 公開日 2023-06-21 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex. Nat Commun, 14, 2023
3KNC	Crystal structure of the CeNA-RNA hybrid octamer ce(GCGTAGCG):r(CGCUACGC) 分子名称: 5'-D(*(XGR)P*(XCR)P*(XGR)P*(XTR)P*(XAR)P*(XGR)P*(XCR)P*(XGR)P*(XGR))-3', 5'-R(*CP*GP*CP*UP*AP*CP*GP*C)-3', MAGNESIUM ION 著者 Ovaere, M, Van Meervelt, L. 登録日 2009-11-12 公開日 2010-12-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Crystal Structure of the CeNA:RNA Hybrid ce(GCGTAGCG):r(CGCUACGC). Chemistry, 17, 2011
6NIT	Human Argonaute2-miR-122 bound to a target RNA with four central mismatches (bu4) 分子名称: Protein argonaute-2, RNA (5'-R(P*AP*AP*CP*AP*CP*CP*AP*UP*CP*CP*AP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') 著者 Sheu-Gruttadauria, J, MacRae, I.J. 登録日 2018-12-31 公開日 2019-08-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Structural Basis for Target-Directed MicroRNA Degradation. Mol.Cell, 75, 2019
5WEA	Human Argonaute2 Helix-7 Mutant 分子名称: PHENOL, Protein argonaute-2, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*U)-3') 著者 Schirle, N.T, Klum, S.M, MacRae, I.J. 登録日 2017-07-08 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition. EMBO J., 37, 2018
1R6Z	The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion) 分子名称: Chimera of Maltose-binding periplasmic protein and Argonaute 2, NICKEL (II) ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Song, J.J, Liu, J, Tolia, N.H, Schneiderman, J, Smith, S.K, Martienssen, R.A, Hannon, G.J, Joshua-Tor, L. 登録日 2003-10-17 公開日 2004-01-13 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat.Struct.Biol., 10, 2003
6CBD	Crystal Structure of Human Argonaute2 Bound to Three Tryptophans 分子名称: Guide RNA, ISOPROPYL ALCOHOL, MAGNESIUM ION, ... 著者 Sheu-Gruttadauria, J, MacRae, I.J. 登録日 2018-02-02 公開日 2018-04-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.203 Å) 主引用文献 Phase Transitions in the Assembly and Function of Human miRISC. Cell, 173, 2018
3G7L	Chromodomain of Chp1 in complex with Histone H3K9me3 peptide 分子名称: ACETIC ACID, Chromo domain-containing protein 1, Histone H3.1/H3.2, ... 著者 Schalch, T, Joshua-Tor, L. 登録日 2009-02-10 公開日 2009-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin Mol.Cell, 34, 2009
4Z4F	Human Argonaute2 Bound to t1-DAP Target RNA 分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2015-04-02 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. Elife, 4, 2015
4Z4D	Human Argonaute2 Bound to t1-G Target RNA 分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2015-04-02 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. Elife, 4, 2015
4Z4C	Human Argonaute2 Bound to t1-C Target RNA 分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2015-04-02 公開日 2015-09-23 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.303 Å) 主引用文献 Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. Elife, 4, 2015
4Z4E	Human Argonaute2 Bound to t1-U Target RNA 分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2015-04-02 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. Elife, 4, 2015
4Z4G	Human Argonaute2 Bound to t1-Inosine Target RNA 分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2015-04-02 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. Elife, 4, 2015

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