PDB: 46188 件ウェブページステータス検索Chemie searchBIRD

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6MD1	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and Oleic acid 分子名称: 2-chloro-5-nitro-N-phenylbenzamide, OLEIC ACID, Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2018-09-03 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018
1DF7	DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE 分子名称: DIHYDROFOLATE REDUCTASE, GLYCEROL, METHOTREXATE, ... 著者 Li, R, Sirawaraporn, R, Chitnumsub, P, Sirawaraporn, W, Wooden, J, Athappilly, F, Turley, S, Hol, W.G. 登録日 1999-11-17 公開日 2000-03-09 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J.Mol.Biol., 295, 2000
1DFJ	RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A 分子名称: RIBONUCLEASE A, RIBONUCLEASE INHIBITOR, SULFATE ION 著者 Kobe, B, Deisenhofer, J. 登録日 1996-06-29 公開日 1997-01-11 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A structural basis of the interactions between leucine-rich repeats and protein ligands. Nature, 374, 1995
1DG7	DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210 分子名称: 1-[3-(4-BROMO-PHENOXY)-PROPOXY]-6,6-DIMETHYL-1.6-DIHYDRO-[1,3,5]TRIAZINE-2,4-DIAMINE, DIHYDROFOLATE REDUCTASE, GLYCEROL, ... 著者 Li, R, Sirawaraporn, R, Chitnumsub, P, Sirawaraporn, W, Wooden, J, Athappilly, F, Turley, S, Hol, W.G. 登録日 1999-11-23 公開日 2000-03-09 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J.Mol.Biol., 295, 2000
6MCZ	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Arachidonic Acid 分子名称: ARACHIDONIC ACID, Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2018-09-03 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018
7C4O	Solution structure of the Orange domain from human protein HES1 分子名称: Transcription factor HES-1 著者 Fan, J.S, Nayak, A, Swaminathan, K. 登録日 2020-05-18 公開日 2021-05-19 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Induction of Transcriptional Inhibitor Hairy and Enhancer of Split Homolog-1 and the Related Repression of Tumor-Suppressor Thioredoxin-Interacting Protein Are Important Components of Cell-Transformation Program Imposed by Oncogenic Kinase Nucleophosmin-Anaplastic Lymphoma Kinase. Am J Pathol, 2022
4Z3P	MATE transporter ClbM in complex with Rb+ 分子名称: CACODYLATE ION, Putative drug/sodium antiporter, RUBIDIUM ION 著者 Mousa, J.J, Bruner, S.D. 登録日 2015-03-31 公開日 2016-01-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 MATE transport of the E. coli-derived genotoxin colibactin. Nat Microbiol, 1, 2016
6LXA	X-ray structure of human PPARalpha ligand binding domain-eicosapentaenoic acid (EPA) co-crystals obtained by delipidation and cross-seeding 分子名称: 5,8,11,14,17-EICOSAPENTAENOIC ACID, GLYCEROL, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. 登録日 2020-02-10 公開日 2020-11-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
8P0A	Human Cohesin ATPase module 分子名称: 64-kDa C-terminal product, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Landwerlin, P, Durand, A, Diebold-Durand, M.-L, Romier, C. 登録日 2023-05-10 公開日 2024-09-11 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Human Cohesin ATPase module To Be Published
1DGV	HOMOLOGY-BASED MODEL OF APO CIB (CALCIUM-AND INTEGRIN-BINDING PROTEIN) 分子名称: APO CIB 著者 Hwang, P.M, Vogel, H.J. 登録日 1999-11-25 公開日 1999-12-08 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structures of the platelet calcium- and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies. J.Mol.Recog., 13, 2000
4Z3N	Crystal structure of the MATE transporter ClbM 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CACODYLATE ION, Putative drug/sodium antiporter 著者 Mousa, J.J, Bruner, S.D. 登録日 2015-03-31 公開日 2016-01-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 MATE transport of the E. coli-derived genotoxin colibactin. Nat Microbiol, 1, 2016
7RDX	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - open class 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-11-24 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
7WOX	PPARgamma antagonist (MMT-160)- PPARgamma LBD complex 分子名称: N-[[5-(3-phenylprop-2-ynoylamino)-2-propoxy-phenyl]methyl]-4-pyrimidin-2-yl-benzamide, Peroxisome proliferator-activated receptor gamma 著者 Yoshizawa, M, Aoyama, T, Itoh, T, Miyachi, H. 登録日 2022-01-22 公開日 2022-04-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Arylalkynyl amide-type peroxisome proliferator-activated receptor gamma (PPAR gamma )-selective antagonists covalently bind to the PPAR gamma ligand binding domain with a unique binding mode. Bioorg.Med.Chem.Lett., 64, 2022
1DMB	REFINED 1.8 ANGSTROMS STRUCTURE REVEALS THE MECHANISM OF BINDING OF A CYCLIC SUGAR, BETA-CYCLODEXTRIN, TO THE MALTODEXTRIN BINDING PROTEIN 分子名称: Cycloheptakis-(1-4)-(alpha-D-glucopyranose), D-MALTODEXTRIN BINDING PROTEIN 著者 Sharff, A.J, Quiocho, F.A. 登録日 1993-06-10 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Refined 1.8-A structure reveals the mode of binding of beta-cyclodextrin to the maltodextrin binding protein. Biochemistry, 32, 1993
1DOA	Structure of the rho family gtp-binding protein cdc42 in complex with the multifunctional regulator rhogdi 分子名称: GERAN-8-YL GERAN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Hoffman, G.R, Nassar, N, Cerione, R.C. 登録日 1999-12-20 公開日 2000-02-09 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell(Cambridge,Mass.), 100, 2000
6LOC	Crystal structure of RORgammat with ligand C46D bound 分子名称: 6-cyclobutyloxy-9-ethyl-~{N}-[(4-ethylsulfonylphenyl)methyl]carbazole-3-carboxamide, Nuclear receptor ROR-gamma 著者 Feng, Y, Shijie, C. 登録日 2020-01-04 公開日 2021-01-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.20014858 Å) 主引用文献 Crystal structure of RORgammat with ligand C46D bound To Be Published
7RDZ	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - apo class 分子名称: ADENOSINE-5'-DIPHOSPHATE, Helicase, MAGNESIUM ION, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-11-24 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
7RE3	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-11-24 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
7D8X	CryoEM structure of human gamma-secretase in complex with E2012 and L685458 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y. 登録日 2020-10-11 公開日 2021-01-27 最終更新日 2021-02-03 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
7RE1	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC (composite) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-12-01 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.91 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
6LX8	X-ray structure of human PPARalpha ligand binding domain-oleic acid co-crystals obtained by delipidation and cross-seeding 分子名称: GLYCEROL, OLEIC ACID, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. 登録日 2020-02-10 公開日 2020-11-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
7RDY	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - engaged class 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-12-01 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
7RE0	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - swiveled class 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Helicase, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-12-01 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
7RE2	SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(1)-RTC 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2021-07-12 公開日 2021-12-01 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29, 2022
1DL0	SOLUTION STRUCTURE OF THE INSECTICIDAL NEUROTOXIN J-ATRACOTOXIN-HV1C 分子名称: J-ATRACOTOXIN-HV1C 著者 Wang, X.H, King, G.F. 登録日 1999-12-08 公開日 2000-09-15 最終更新日 2022-02-16 実験手法 SOLUTION NMR 主引用文献 Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge. Nat.Struct.Biol., 7, 2000

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