7WOX

PPARgamma antagonist (MMT-160)- PPARgamma LBD complex

Summary for 7WOX

Entry DOI	10.2210/pdb7wox/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, N-[[5-(3-phenylprop-2-ynoylamino)-2-propoxy-phenyl]methyl]-4-pyrimidin-2-yl-benzamide (3 entities in total)
Functional Keywords	ppargamma, mtt160, covalent modifier, nuclear hormone receptor, antagonist, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	63389.59
Authors	Yoshizawa, M.,Aoyama, T.,Itoh, T.,Miyachi, H. (deposition date: 2022-01-22, release date: 2022-04-13, Last modification date: 2023-11-29)
Primary citation	Yoshizawa, M.,Aoyama, T.,Itoh, T.,Miyachi, H. Arylalkynyl amide-type peroxisome proliferator-activated receptor gamma (PPAR gamma )-selective antagonists covalently bind to the PPAR gamma ligand binding domain with a unique binding mode. Bioorg.Med.Chem.Lett., 64:128676-128676, 2022 Cited by PubMed: 35301139 DOI: 10.1016/j.bmcl.2022.128676 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation