1DF7

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE

Summary for 1DF7

Entry DOI	10.2210/pdb1df7/pdb
Related	1DG5 1DG7 1DG8
Descriptor	DIHYDROFOLATE REDUCTASE, SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywords	dihydrofolate reductase, structure-based inhibitor design, folateanalogs, rossmann fold, nicotinamide adenine dinucleotide, methotrexate, tuberculosis, oxidoreductase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	19325.29
Authors	Li, R.,Sirawaraporn, R.,Chitnumsub, P.,Sirawaraporn, W.,Wooden, J.,Athappilly, F.,Turley, S.,Hol, W.G. (deposition date: 1999-11-17, release date: 2000-03-09, Last modification date: 2024-02-07)
Primary citation	Li, R.,Sirawaraporn, R.,Chitnumsub, P.,Sirawaraporn, W.,Wooden, J.,Athappilly, F.,Turley, S.,Hol, W.G. Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J.Mol.Biol., 295:307-323, 2000 Cited by PubMed: 10623528 DOI: 10.1006/jmbi.1999.3328 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation