7RE3

SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer

Summary for 7RE3

Entry DOI	10.2210/pdb7re3/pdb
EMDB information	24432
Descriptor	RNA-directed RNA polymerase, ALUMINUM FLUORIDE, CHAPSO, ... (11 entities in total)
Functional Keywords	rna-dependent rna polymerase, viral replication-transcription complex, transcription, viral proteins, replication-transcription complex, replication/transcription
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More
Total number of polymer chains	16
Total formula weight	653397.17
Authors	Chen, J.,Malone, B.,Campbell, E.A.,Darst, S.A. (deposition date: 2021-07-12, release date: 2021-11-24, Last modification date: 2022-03-30)
Primary citation	Chen, J.,Wang, Q.,Malone, B.,Llewellyn, E.,Pechersky, Y.,Maruthi, K.,Eng, E.T.,Perry, J.K.,Campbell, E.A.,Shaw, D.E.,Darst, S.A. Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nat.Struct.Mol.Biol., 29:250-260, 2022 Cited by PubMed: 35260847 DOI: 10.1038/s41594-022-00734-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.33 Å)

Structure validation