7RE3
SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, J (A, G) | RNA-directed RNA polymerase | polymer | 932 | 106781.0 | 2 | UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | Pol, RdRp, Non-structural protein 12, nsp12 |
| 2 | B, D, G, L (B, D, H, J) | Non-structural protein 8 | polymer | 199 | 22034.2 | 4 | UniProt (P0DTD1) Pfam (PF08717) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | nsp8 |
| 3 | C, K (C, I) | Non-structural protein 7 | polymer | 88 | 9748.4 | 2 | UniProt (P0DTD1) Pfam (PF08716) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | nsp7 |
| 4 | E, F, M, N (E, F, K, L) | Helicase | polymer | 605 | 67354.0 | 4 | UniProt (P0DTD1) Pfam (PF20632) Pfam (PF20633) Pfam (PF20631) Pfam (PF13087) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | Hel, Non-structural protein 13, nsp13 |
| 5 | H, O (P, Q) | Product RNA | polymer | 35 | 11141.6 | 2 | synthetic construct | ||
| 6 | I, P (T, U) | Template RNA | polymer | 55 | 17573.4 | 2 | synthetic construct | ||
| 7 | BA, CA, DA, HA, IA... (F, G, K, A, L...) | ZINC ION | non-polymer | 65.4 | 16 | Chemie (ZN) | |||
| 8 | FA, JA, PA, S, WA... (F, G, K, A, L...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) PubChem (888) | |||
| 9 | EA, KA, OA, T, VA... (F, G, K, A, L...) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 6 | Chemie (ADP) | |||
| 10 | GA, QA, XA, Z (F, K, L, E) | ALUMINUM FLUORIDE | non-polymer | 84.0 | 4 | Chemie (AF3) PubChem (2124) | |||
| 11 | AA, RA (E, K) | CHAPSO | non-polymer | 631.9 | 2 | Chemie (1N7) PubChem (16402373) PubChem (44119969) PubChem (44660322) PubChem (23636791) PubChem (23639399) PubChem (122146) PubChem (53393747) PubChem (50987332) PubChem (71464051) PubChem (3253739) PubChem (71305076) PubChem (90479263) PubChem (96545191) PubChem (124745618) PubChem (124901558) PubChem (124905421) PubChem (125027410) PubChem (10009199) PubChem (96327541) PubChem (96327542) PubChem (96327543) PubChem (96327544) PubChem (96545192) PubChem (102565431) PubChem (121392376) PubChem (122130148) PubChem (9895487) PubChem (144605089) PubChem (124901556) PubChem (124901561) PubChem (124901563) PubChem (124905422) PubChem (125027411) PubChem (129537355) PubChem (129537356) PubChem (145705472) PubChem (146030291) PubChem (146159852) |
Sequence modifications
B, D, H, J: 1 - 198 (UniProt: P0DTD1)
C, I: 1 - 83 (UniProt: P0DTD1)
E, F, K, L: 1 - 601 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Val -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Met 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 648041.9 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 5355.3 | |
| All* | Total formula weight | 653397.2 |
