7RE3
SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, J (A, G) | RNA-directed RNA polymerase | polymer | 932 | 106781.0 | 2 | UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | Pol, RdRp, Non-structural protein 12, nsp12 |
| 2 | B, D, G, L (B, D, H, J) | Non-structural protein 8 | polymer | 199 | 22034.2 | 4 | UniProt (P0DTD1) Pfam (PF08717) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | nsp8 |
| 3 | C, K (C, I) | Non-structural protein 7 | polymer | 88 | 9748.4 | 2 | UniProt (P0DTD1) Pfam (PF08716) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | nsp7 |
| 4 | E, F, M, N (E, F, K, L) | Helicase | polymer | 605 | 67354.0 | 4 | UniProt (P0DTD1) Pfam (PF20632) Pfam (PF20633) Pfam (PF20631) Pfam (PF13087) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | Hel, Non-structural protein 13, nsp13 |
| 5 | H, O (P, Q) | Product RNA | polymer | 35 | 11141.6 | 2 | synthetic construct | ||
| 6 | I, P (T, U) | Template RNA | polymer | 55 | 17573.4 | 2 | synthetic construct | ||
| 7 | BA, CA, DA, HA, IA... (F, G, K, A, L...) | ZINC ION | non-polymer | 65.4 | 16 | Chemie (ZN) | |||
| 8 | FA, JA, PA, S, WA... (F, G, K, A, L...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 9 | EA, KA, OA, T, VA... (F, G, K, A, L...) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 6 | Chemie (ADP) | |||
| 10 | GA, QA, XA, Z (F, K, L, E) | ALUMINUM FLUORIDE | non-polymer | 84.0 | 4 | Chemie (AF3) | |||
| 11 | AA, RA (E, K) | CHAPSO | non-polymer | 631.9 | 2 | Chemie (1N7) |
Sequence modifications
B, D, H, J: 1 - 198 (UniProt: P0DTD1)
C, I: 1 - 83 (UniProt: P0DTD1)
E, F, K, L: 1 - 601 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Val -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Met 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 648041.9 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 5355.3 | |
| All* | Total formula weight | 653397.2 |
