Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7RE3

SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005524	molecular_function	ATP binding
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0008242	molecular_function	omega peptidase activity
B	0016740	molecular_function	transferase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0008242	molecular_function	omega peptidase activity
C	0016740	molecular_function	transferase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0008242	molecular_function	omega peptidase activity
D	0016740	molecular_function	transferase activity
E	0004386	molecular_function	helicase activity
E	0005524	molecular_function	ATP binding
E	0008270	molecular_function	zinc ion binding
F	0004386	molecular_function	helicase activity
F	0005524	molecular_function	ATP binding
F	0008270	molecular_function	zinc ion binding
G	0003723	molecular_function	RNA binding
G	0003968	molecular_function	RNA-directed RNA polymerase activity
G	0005524	molecular_function	ATP binding
G	0006351	biological_process	DNA-templated transcription
G	0039694	biological_process	viral RNA genome replication
H	0004197	molecular_function	cysteine-type endopeptidase activity
H	0008242	molecular_function	omega peptidase activity
H	0016740	molecular_function	transferase activity
I	0004197	molecular_function	cysteine-type endopeptidase activity
I	0008242	molecular_function	omega peptidase activity
I	0016740	molecular_function	transferase activity
J	0004197	molecular_function	cysteine-type endopeptidase activity
J	0008242	molecular_function	omega peptidase activity
J	0016740	molecular_function	transferase activity
K	0004386	molecular_function	helicase activity
K	0005524	molecular_function	ATP binding
K	0008270	molecular_function	zinc ion binding
L	0004386	molecular_function	helicase activity
L	0005524	molecular_function	ATP binding
L	0008270	molecular_function	zinc ion binding

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	12
Details	LIPOCALIN Lipocalin signature. GTS..KFYGGWHNM

Chain	Residue	Details
A	GLY590-MET601

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	508
Details	Domain: {"description":"NiRAN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01292","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	50
Details	Repeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	196
Details	Domain: {"description":"Nsp12 Interface","evidences":[{"source":"PROSITE-ProRule","id":"PRU01344","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	324
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	428
Details	Region: {"description":"RdRp Fingers N-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	20
Details	Region: {"description":"Interaction with RMP Remdesivir","evidences":[{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	76
Details	Region: {"description":"RdRp Palm N-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	116
Details	Region: {"description":"RdRp Fingers C-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	270
Details	Region: {"description":"RdRp Palm C-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	6
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01344","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	108
Details	Repeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	448
Details	Domain: {"description":"CV ZBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00986","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	80
Details	Repeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	724
Details	Domain: {"description":"(+)RNA virus helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00990","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00986","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00990","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)