7RE3
SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0008242 | molecular_function | omega peptidase activity |
| B | 0016740 | molecular_function | transferase activity |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0008242 | molecular_function | omega peptidase activity |
| C | 0016740 | molecular_function | transferase activity |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0008242 | molecular_function | omega peptidase activity |
| D | 0016740 | molecular_function | transferase activity |
| E | 0004386 | molecular_function | helicase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0008270 | molecular_function | zinc ion binding |
| F | 0004386 | molecular_function | helicase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0008270 | molecular_function | zinc ion binding |
| G | 0003723 | molecular_function | RNA binding |
| G | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0006351 | biological_process | DNA-templated transcription |
| G | 0039694 | biological_process | viral RNA genome replication |
| H | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| H | 0008242 | molecular_function | omega peptidase activity |
| H | 0016740 | molecular_function | transferase activity |
| I | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| I | 0008242 | molecular_function | omega peptidase activity |
| I | 0016740 | molecular_function | transferase activity |
| J | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| J | 0008242 | molecular_function | omega peptidase activity |
| J | 0016740 | molecular_function | transferase activity |
| K | 0004386 | molecular_function | helicase activity |
| K | 0005524 | molecular_function | ATP binding |
| K | 0008270 | molecular_function | zinc ion binding |
| L | 0004386 | molecular_function | helicase activity |
| L | 0005524 | molecular_function | ATP binding |
| L | 0008270 | molecular_function | zinc ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00213 |
| Number of Residues | 12 |
| Details | LIPOCALIN Lipocalin signature. GTS..KFYGGWHNM |
| Chain | Residue | Details |
| A | GLY590-MET601 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00986, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ |
| Chain | Residue | Details |
| E | CYS5 | |
| E | CYS55 | |
| E | CYS72 | |
| E | HIS75 | |
| F | CYS5 | |
| F | CYS8 | |
| F | CYS16 | |
| F | CYS19 | |
| F | CYS26 | |
| F | CYS29 | |
| F | HIS33 | |
| E | CYS8 | |
| F | HIS39 | |
| F | CYS50 | |
| F | CYS55 | |
| F | CYS72 | |
| F | HIS75 | |
| K | CYS5 | |
| K | CYS8 | |
| K | CYS16 | |
| K | CYS19 | |
| K | CYS26 | |
| E | CYS16 | |
| K | CYS29 | |
| K | HIS33 | |
| K | HIS39 | |
| K | CYS50 | |
| K | CYS55 | |
| K | CYS72 | |
| K | HIS75 | |
| L | CYS5 | |
| L | CYS8 | |
| L | CYS16 | |
| E | CYS19 | |
| L | CYS19 | |
| L | CYS26 | |
| L | CYS29 | |
| L | HIS33 | |
| L | HIS39 | |
| L | CYS50 | |
| L | CYS55 | |
| L | CYS72 | |
| L | HIS75 | |
| E | CYS26 | |
| E | CYS29 | |
| E | HIS33 | |
| E | HIS39 | |
| E | CYS50 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00990 |
| Chain | Residue | Details |
| E | GLY282 | |
| F | GLY282 | |
| K | GLY282 | |
| L | GLY282 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| E | GLN601 | |
| F | GLN601 | |
| K | GLN601 | |
| L | GLN601 | |
| G | HIS295 | |
| G | CYS301 | |
| G | CYS306 | |
| G | CYS310 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691, ECO:0007744|PDB:7CYQ |
| Chain | Residue | Details |
| A | CYS487 | |
| A | HIS642 | |
| A | CYS646 | |
| G | CYS487 | |
| G | HIS642 | |
| G | CYS646 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01293, ECO:0000269|PubMed:32358203, ECO:0000269|PubMed:32526208, ECO:0000269|PubMed:33232691 |
| Chain | Residue | Details |
| A | CYS645 | |
| G | CYS645 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| A | GLN932 | |
| G | GLN932 |
