PDB: 4939 件ウェブページステータス検索Chemie searchBIRD

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3NNV	Crystal structure of P38 alpha in complex with DP437 分子名称: 1-{3-tert-butyl-1-[4-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}-3-naphthalen-1-ylurea, Mitogen-activated protein kinase 14 著者 Abendroth, J. 登録日 2010-06-24 公開日 2010-09-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region Bioorg.Med.Chem.Lett., 20, 2010
4HPU	Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying partial phosphoryl transfer of AMP-PNP onto a substrate peptide 分子名称: MAGNESIUM ION, MYRISTIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Bastidas, A.C, Steichen, J.M, Wu, J, Taylor, S.S. 登録日 2012-10-24 公開日 2013-03-20 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Phosphoryl transfer by protein kinase a is captured in a crystal lattice. J.Am.Chem.Soc., 135, 2013
3OD6	Crystal structure of p38alpha Y323T active mutant 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Livnah, O, Tzarum, N. 登録日 2010-08-11 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.682 Å) 主引用文献 Active mutants of the TCR-mediated p38alpha alternative activation site show changes in the phosphorylation lip and DEF site formation. J.Mol.Biol., 405, 2011
3NRM	Imidazo[1,2-a]pyrazine-based Aurora Kinase Inhibitors 分子名称: N-(3-methylisothiazol-5-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine, Serine/threonine-protein kinase 6 著者 Hruza, A. 登録日 2010-06-30 公開日 2010-08-18 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3NUY	phosphoinositide-dependent kinase-1 (PDK1) with fragment17 分子名称: GLYCEROL, PkB-like, SULFATE ION, ... 著者 Campobasso, N, Ward, P. 登録日 2010-07-07 公開日 2011-05-25 最終更新日 2018-10-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery. ACS Med Chem Lett, 1, 2010
3MBL	Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP 分子名称: 5-acetyl-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Dougan, D.R, Mol, C.D. 登録日 2010-03-25 公開日 2010-07-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
3MH3	Mutagenesis of p38 MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Namboodiri, H.V, Karpusas, M, Bukhtiyarova, M, Springman, E.B. 登録日 2010-04-07 公開日 2010-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state. Biochemistry, 46, 2007
3MH2	Mutagenesis of p38 MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Namboodiri, H.V, Karpusas, M, Bukhtiyarova, M, Springman, E.B. 登録日 2010-04-07 公開日 2010-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state. Biochemistry, 46, 2007
4IAK	Low temperature X-ray structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20 分子名称: ADENOSINE-5'-DIPHOSPHATE, CARBONATE ION, STRONTIUM ION, ... 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-06 公開日 2013-06-12 最終更新日 2013-12-18 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
4IAY	Room temperature X-ray Structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20 分子名称: ADENOSINE-5'-DIPHOSPHATE, STRONTIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-07 公開日 2013-06-12 最終更新日 2013-12-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
4HNI	crystal structure of ck1e in complex with PF4800567 分子名称: 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Casein kinase I isoform epsilon, SULFATE ION 著者 Huang, X, Long, A.M, Zhao, H. 登録日 2012-10-19 公開日 2012-11-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J.Med.Chem., 55, 2012
3MGY	Mutagenesis of p38 MAP Kinase eshtablishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Namboodiri, H.V, Karpusas, M, Bukhtiyarova, M, Springman, E.B. 登録日 2010-04-07 公開日 2010-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state. Biochemistry, 46, 2007
3MFU	CASK-4M CaM Kinase Domain, AMPPNP-Mn2+ 分子名称: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Peripheral plasma membrane protein CASK 著者 Wahl, M.C, Mukherjee, K. 登録日 2010-04-03 公開日 2010-04-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Evolution of CASK into a Mg2+-sensitive kinase. Sci.Signal., 3, 2010
4I5H	Crystal Structure of a Double Mutant Rat Erk2 Complexed With a Type II Quinazoline Inhibitor 分子名称: Mitogen-activated protein kinase 1, N-{3-[2-(cyclopropylamino)quinazolin-6-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide 著者 Hari, S.B, Maly, D.J, Merritt, E.A. 登録日 2012-11-28 公開日 2013-07-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Sequence determinants of a specific inactive protein kinase conformation. Chem.Biol., 20, 2013
3MA3	Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a naphtho-difuran ligand 分子名称: Pimtide, Proto-oncogene serine/threonine-protein kinase pim-1, naphtho[2,1-b:7,6-b']difuran-2,8-dicarboxylic acid 著者 Filippakopoulos, P, Bullock, A, Fedorov, O, Vollmar, M, von Delft, F, Cochet, C, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2010-03-23 公開日 2010-04-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights. Faseb J., 24, 2010
3MH0	Mutagenesis of p38 MAP Kinase eshtablishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Namboodiri, H.V, Karpusas, M, Bukhtiyarova, M, Springman, E.B. 登録日 2010-04-07 公開日 2010-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state. Biochemistry, 46, 2007
3M1S	Structure of Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3 分子名称: Glycogen synthase kinase-3 beta, Ruthenium pyridocarbazole 著者 Atilla-Gokcumen, G.E, Di Costanzo, L, Zimmermann, G, Meggers, E. 登録日 2010-03-05 公開日 2010-12-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.134 Å) 主引用文献 Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3beta J.Biol.Inorg.Chem., 16, 2011
4IAA	Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine 分子名称: 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, Serine/threonine-protein kinase pim-1 著者 Zhang, W, Wan, X, Li, W, Xie, Y, Huang, N. 登録日 2012-12-06 公開日 2013-12-18 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine To be Published
4IB5	Structure of human protein kinase CK2 catalytic subunit in complex with a CK2beta-competitive cyclic peptide 分子名称: CHLORIDE ION, CK2beta-derived cyclic peptide, Casein kinase II subunit alpha, ... 著者 Raaf, J, Guerra, B, Neundorf, I, Bopp, B, Issinger, O.-G, Jose, J, Pietsch, M, Niefind, K. 登録日 2012-12-08 公開日 2013-03-20 最終更新日 2013-06-05 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 First structure of protein kinase CK2 catalytic subunit with an effective CK2 beta-competitive ligand Acs Chem.Biol., 8, 2013
4IAF	Room temperature X-ray Structure OF cAMP dependent protein kinase A in complex with high Mg2+ concentration, ADP and phosphorylated peptide pSP20 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Gerlits, O, Kovalevsky, A. 登録日 2012-12-06 公開日 2013-06-12 最終更新日 2013-12-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20. Biochemistry, 52, 2013
3NR9	Structure of human CDC2-like kinase 2 (CLK2) 分子名称: (5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Dual specificity protein kinase CLK2 著者 Chaikuad, A, Savitsky, P, Krojer, T, Muniz, J.R.C, Filippakopoulos, P, Rellos, P, Keates, T, Fedorov, O, Pike, A.C.W, Eswaran, J, Berridge, G, Phillips, C, Zhang, Y, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2010-06-30 公開日 2010-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structure of human CDC2-like kinase 2 (CLK2) To be Published
4IAN	Crystal Structure of apo Human PRPF4B kinase domain 分子名称: SULFATE ION, Serine/threonine-protein kinase PRP4 homolog 著者 Mechin, I, Haas, K, Chen, X, Zhang, Y, McLean, L. 登録日 2012-12-06 公開日 2013-08-28 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288, 2013
4I41	Crystal Structure of human Ser/Thr kinase Pim1 in complex with mitoxantrone 分子名称: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, Serine/threonine-protein kinase pim-1 著者 Zhang, W, Wan, X, Xie, Y, Huang, N. 登録日 2012-11-27 公開日 2013-12-11 最終更新日 2019-07-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J. Med. Chem., 56, 2013
3NUU	phosphoinositide-dependent kinase-1 (PDK1) with fragment11 分子名称: 3,4-dihydroisoquinolin-1(2H)-one, GLYCEROL, PkB-like, ... 著者 Campobasso, N, Ward, P. 登録日 2010-07-07 公開日 2011-05-25 最終更新日 2018-10-10 実験手法 X-RAY DIFFRACTION (1.9803 Å) 主引用文献 Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery. ACS Med Chem Lett, 1, 2010
3O8U	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding 分子名称: 1-(5-TERT-BUTYL-2-METHYL-2H-PYRAZOL-3-YL)-3-(4-CHLORO-PHENYL)-UREA, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Namboodiri, H.V, Karpusas, M, Bukhtiyarova, M, Springman, E.B. 登録日 2010-08-03 公開日 2010-09-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding To be Published

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