3MA3

Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a naphtho-difuran ligand

Summary for 3MA3

Entry DOI	10.2210/pdb3ma3/pdb
Descriptor	Proto-oncogene serine/threonine-protein kinase pim-1, Pimtide, naphtho[2,1-b:7,6-b']difuran-2,8-dicarboxylic acid, ... (4 entities in total)
Functional Keywords	oncogene, kinase, serine-threonine, pim1, structural genomics consortium, sgc, alternative initiation, atp-binding, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, host-virus interaction, viral immunoevasion, virion, virulence, cell cycle, cell membrane
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	2
Total formula weight	36907.82
Authors	Filippakopoulos, P.,Bullock, A.,Fedorov, O.,Vollmar, M.,von Delft, F.,Cochet, C.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-03-23, release date: 2010-04-14, Last modification date: 2023-09-06)
Primary citation	Lopez-Ramos, M.,Prudent, R.,Moucadel, V.,Sautel, C.F.,Barette, C.,Lafanechere, L.,Mouawad, L.,Grierson, D.,Schmidt, F.,Florent, J.C.,Filippakopoulos, P.,Bullock, A.N.,Knapp, S.,Reiser, J.B.,Cochet, C. New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights. Faseb J., 24:3171-3185, 2010 Cited by PubMed: 20400536 DOI: 10.1096/fj.09-143743 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation