3MA3
Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a naphtho-difuran ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene serine/threonine-protein kinase pim-1 | polymer | 313 | 35670.5 | 1 | UniProt (P11309) Pfam (PF00069) | Homo sapiens (human) | |
| 2 | B (B) | Pimtide | polymer | 7 | 941.1 | 1 | consensus PIM1 substrate peptide | ||
| 3 | C (A) | naphtho[2,1-b:7,6-b']difuran-2,8-dicarboxylic acid | non-polymer | 296.2 | 1 | Chemie (01I) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A: 2 - 312 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Met 1 | - | expression tag |
| Gly 250 | Arg 341 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36611.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 296.2 | |
| All* | Total formula weight | 36907.8 |
