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4I41

Crystal Structure of human Ser/Thr kinase Pim1 in complex with mitoxantrone

Summary for 4I41
Entry DOI10.2210/pdb4i41/pdb
DescriptorSerine/threonine-protein kinase pim-1, 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE (3 entities in total)
Functional Keywordsser/thr kinase, mitoxantrone, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight33426.83
Authors
Zhang, W.,Wan, X.,Xie, Y.,Huang, N. (deposition date: 2012-11-27, release date: 2013-12-11, Last modification date: 2019-07-17)
Primary citationWan, X.,Zhang, W.,Li, L.,Xie, Y.,Li, W.,Huang, N.
A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling.
J. Med. Chem., 56:2619-2629, 2013
Cited by
PubMed: 23442188
DOI: 10.1021/jm400045y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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