4I41
Crystal Structure of human Ser/Thr kinase Pim1 in complex with mitoxantrone
Summary for 4I41
Entry DOI | 10.2210/pdb4i41/pdb |
Descriptor | Serine/threonine-protein kinase pim-1, 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE (3 entities in total) |
Functional Keywords | ser/thr kinase, mitoxantrone, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33426.83 |
Authors | |
Primary citation | Wan, X.,Zhang, W.,Li, L.,Xie, Y.,Li, W.,Huang, N. A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J. Med. Chem., 56:2619-2629, 2013 Cited by PubMed: 23442188DOI: 10.1021/jm400045y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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