Low temperature X-ray structure of cAMP dependent protein kinase A in complex with high Sr2+ concentration, ADP and phosphorylated peptide pSP20

Summary for 4IAK

Related4IAC 4IAD 4IAF 4IAI 4IAY 4IAZ 4IB0 4IB1 4IB3
DescriptorcAMP-dependent protein kinase catalytic subunit alpha, phosphorylated pseudo-substrate peptide pSP20, STRONTIUM ION, ... (6 entities in total)
Functional Keywordskinase enzyme, phosphotransfer, phosphorylation, transferase-peptide complex, transferase/peptide
Biological sourceMus musculus (mouse)
Cellular locationCytoplasm. Isoform 2: Cell projection, cilium, flagellum (By similarity) P05132
Total number of polymer chains2
Total molecular weight44507.99
Gerlits, O.,Kovalevsky, A. (deposition date: 2012-12-06, release date: 2013-06-12, Last modification date: 2013-12-18)
Primary citation
Gerlits, O.,Waltman, M.J.,Taylor, S.,Langan, P.,Kovalevsky, A.
Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20.
Biochemistry, 52:3721-3727, 2013
PubMed: 23672593 (PDB entries with the same primary citation)
DOI: 10.1021/bi400066a
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20670 5.2% 9.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21