6UGM
 
 | | Structural basis of COMPASS eCM recognition of an unmodified nucleosome | | 分子名称: | Bre2, DNA (146-MER), H3 N-terminus, ... | | 著者 | Hsu, P.L, Shi, H, Zheng, N. | | 登録日 | 2019-09-26 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS.
Mol.Cell, 76, 2019
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7MBM
 | | Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode01 | | 分子名称: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Dou, Y, Cho, U. | | 登録日 | 2021-04-01 | | 公開日 | 2021-12-29 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY | | 主引用文献 | Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes.
Biochemistry, 61, 2022
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7MBN
 | | Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode02 | | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Dou, Y, Cho, U. | | 登録日 | 2021-04-01 | | 公開日 | 2021-12-29 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY | | 主引用文献 | Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes.
Biochemistry, 61, 2022
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8WA1
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8W9Z
 | | The cryo-EM structure of the Nicotiana tabacum PEP-PAP | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta'', ... | | 著者 | Wu, X.X, Zhang, Y. | | 登録日 | 2023-09-06 | | 公開日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structures of the plant plastid-encoded RNA polymerase.
Cell, 187, 2024
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8WA0
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7AT8
 | | Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2. | | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3.2, ... | | 著者 | Finogenova, K, Benda, C, Schaefer, I.B, Poepsel, S, Strauss, M, Mueller, J. | | 登録日 | 2020-10-29 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3.
Elife, 9, 2020
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7BRE
 | | The crystal structure of MLL2 in complex with ASH2L and RBBP5 | | 分子名称: | Histone-lysine N-methyltransferase 2B, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Li, Y, Zhao, L, Chen, Y. | | 登録日 | 2020-03-28 | | 公開日 | 2020-07-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.803 Å) | | 主引用文献 | Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.
Structure, 28, 2020
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7TD5
 | | Structure of human PRC2-EZH1 containing phosphorylated SUZ12 | | 分子名称: | Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, Polycomb protein SUZ12, ... | | 著者 | Gong, L, Jiao, L, Liu, X. | | 登録日 | 2021-12-30 | | 公開日 | 2022-11-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.994 Å) | | 主引用文献 | CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site.
Nat Commun, 13, 2022
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7KSO
 | | Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 | | 分子名称: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | | 著者 | Grau, D.J, Armache, K.J. | | 登録日 | 2020-11-23 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.
Nat Commun, 12, 2021
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7KSR
 | | PRC2:EZH1_A from a dimeric PRC2 bound to a nucleosome | | 分子名称: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | | 著者 | Grau, D.J, Armache, K.J. | | 登録日 | 2020-11-24 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.
Nat Commun, 12, 2021
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7KTP
 | | PRC2:EZH1_B from a dimeric PRC2 bound to a nucleosome | | 分子名称: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | | 著者 | Grau, D.J, Armache, K.J. | | 登録日 | 2020-11-24 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.
Nat Commun, 12, 2021
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7XPX
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7YRD
 | | histone methyltransferase | | 分子名称: | DNA (146-MER), Histone H2A.Z, Histone H2B 1.1, ... | | 著者 | Li, H, Wang, W.Y. | | 登録日 | 2022-08-09 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1.
Mol.Cell, 83, 2023
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7YRG
 | | histone methyltransferase | | 分子名称: | DNA (146-MER), Histone H2A.Z, Histone H2B 1.1, ... | | 著者 | Li, H, Wang, W.Y. | | 登録日 | 2022-08-09 | | 公開日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1.
Mol.Cell, 83, 2023
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5BJS
 | | Apo ctPRC2 in an autoinhibited state | | 分子名称: | Histone-lysine N-methyltransferase EZH2, Polycomb protein SUZ12, Polycomb Protein EED, ... | | 著者 | Bratkowski, M.A, Liu, X. | | 登録日 | 2016-10-22 | | 公開日 | 2017-06-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.189 Å) | | 主引用文献 | Polycomb repressive complex 2 in an autoinhibited state.
J. Biol. Chem., 292, 2017
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8T9F
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8T9H
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8SWI
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6NZO
 | | Set2 bound to nucleosome | | 分子名称: | DNA (149-MER), Histone H2B 1.1, Histone H3, ... | | 著者 | Halic, M, Bilokapic, S. | | 登録日 | 2019-02-14 | | 公開日 | 2019-08-28 | | 最終更新日 | 2019-09-04 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Nucleosome and ubiquitin position Set2 to methylate H3K36.
Nat Commun, 10, 2019
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8SR6
 | | Crystal structure of legAS4 from Legionella pneumophila subsp. pneumophila with histone H3 (3-17)peptide | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Eukaryotic huntingtin interacting protein B, ... | | 著者 | Xu, C, Chung, I.Y.W, Cygler, M. | | 登録日 | 2023-05-05 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-09-25 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin.
Mbio, 14, 2023
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5CZY
 | | Crystal structure of LegAS4 | | 分子名称: | GLYCEROL, Legionella effector LegAS4, S-ADENOSYLMETHIONINE | | 著者 | Son, J, Hwang, K.Y, Lee, W.C. | | 登録日 | 2015-08-01 | | 公開日 | 2015-09-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of Legionella pneumophila type IV secretion system effector LegAS4
Biochem.Biophys.Res.Commun., 465, 2015
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8T9G
 | | Automethylated PRC2 dimer bound to nucleosome | | 分子名称: | DNA (226-MER), Histone H2A type 1, Histone H2B 1.1, ... | | 著者 | Sauer, P.V, Pavlenko, E, Nogales, E, Poepsel, S. | | 登録日 | 2023-06-23 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | | 主引用文献 | Activation of automethylated PRC2 by dimerization on chromatin.
Mol.Cell, 2024
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8TAS
 | | PRC2 monomer bound to nucleosome | | 分子名称: | DNA (226-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Sauer, P.V, Pavlenko, E, Nogales, E, Poepsel, S. | | 登録日 | 2023-06-27 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Activation of automethylated PRC2 by dimerization on chromatin.
Mol.Cell, 2024
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8TB9
 | | PRC2-J119-450 monomer bound to H1-nucleosome | | 分子名称: | DNA (226-MER), Histone H1.0, Histone H2A type 1, ... | | 著者 | Sauer, P.V, Cookis, T, Pavlenko, E, Nogales, E, Poepsel, S. | | 登録日 | 2023-06-28 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Activation of automethylated PRC2 by dimerization on chromatin.
Mol.Cell, 2024
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