PDB: 479 件ウェブページステータス検索Chemie searchBIRD

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3Q65	Human Aldose Reductase in Complex with NADP+ in Space Group P212121 分子名称: Aldose reductase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Sawaya, M.R, Cascio, D, Balendiran, G.K. 登録日 2010-12-30 公開日 2011-01-19 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 The role of Cys-298 in aldose reductase function. J.Biol.Chem., 286, 2011
3Q67	Human Aldose Reductase C298S mutant in Complex with NADP+ in Space Group P212121 分子名称: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION 著者 Sawaya, M.R, Cascio, D, Balendiran, G.K. 登録日 2010-12-30 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 The role of Cys-298 in aldose reductase function. J.Biol.Chem., 286, 2011
3LQG	Human aldose reductase mutant T113A complexed with IDD388 分子名称: (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID, Aldose reductase, BROMIDE ION, ... 著者 Koch, C, Heine, A, Klebe, G. 登録日 2010-02-09 公開日 2010-12-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors J.Mol.Biol., 406, 2011
3LBO	Human aldose reductase mutant T113C complexed with IDD594 分子名称: Aldose reductase, BROMIDE ION, CITRIC ACID, ... 著者 Koch, C, Heine, A, Klebe, G. 登録日 2010-01-08 公開日 2010-12-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors J.Mol.Biol., 406, 2011
3LEP	Human Aldose Reductase mutant T113C in complex with IDD388 分子名称: (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID, Aldose reductase, BROMIDE ION, ... 著者 Koch, C, Heine, A, Klebe, G. 登録日 2010-01-15 公開日 2010-12-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (0.99 Å) 主引用文献 Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors J.Mol.Biol., 406, 2011
3LQL	Human Aldose Reductase mutant T113A complexed with IDD 594 分子名称: Aldose reductase, BROMIDE ION, CITRIC ACID, ... 著者 Koch, C, Heine, A, Klebe, G. 登録日 2010-02-09 公開日 2010-12-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors J.Mol.Biol., 406, 2011
3LZ3	Human aldose reductase mutant T113S complexed with IDD388 分子名称: (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID, Aldose reductase, BROMIDE ION, ... 著者 Koch, C, Heine, A, Klebe, G. 登録日 2010-03-01 公開日 2010-12-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.03 Å) 主引用文献 Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors J.Mol.Biol., 406, 2011
3LD5	Human aldose reductase mutant T113S complexed with IDD594 分子名称: Aldose reductase, BROMIDE ION, CITRIC ACID, ... 著者 Koch, C, Heine, A, Klebe, G. 登録日 2010-01-12 公開日 2010-12-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors J.Mol.Biol., 406, 2011
3M4H	Human Aldose Reductase mutant T113V complexed with IDD388 分子名称: (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID, Aldose reductase, BROMIDE ION, ... 著者 Koch, C, Heine, A, Klebe, G. 登録日 2010-03-11 公開日 2010-12-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (0.94 Å) 主引用文献 Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors J.Mol.Biol., 406, 2011
3LZ5	Human aldose reductase mutant T113V complexed with IDD594 分子名称: Aldose Reductase, CITRIC ACID, IDD594, ... 著者 Koch, C, Heine, A, Klebe, G. 登録日 2010-03-01 公開日 2010-12-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (0.95 Å) 主引用文献 Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors J.Mol.Biol., 406, 2011
3O0K	Crystal structure of ALDO/KETO reductase from brucella melitensis 分子名称: 1,2-ETHANEDIOL, Aldo/keto reductase, GLYCEROL 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2010-07-19 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of ALDO/KETO reductase from brucella melitensis TO BE PUBLISHED
3N2T	Structure of the glycerol dehydrogenase AKR11B4 from Gluconobacter oxydans 分子名称: Putative oxidoreductase 著者 Richter, N, Breicha, K, Hummel, W, Niefind, K. 登録日 2010-05-19 公開日 2010-07-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Three-Dimensional Structure of AKR11B4, a Glycerol Dehydrogenase from Gluconobacter oxydans, Reveals a Tryptophan Residue as an Accelerator of Reaction Turnover. J.Mol.Biol., 404, 2010
3LUT	A Structural Model for the Full-length Shaker Potassium Channel Kv1.2 分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2, ... 著者 Chen, X, Ni, F, Wang, Q, Ma, J. 登録日 2010-02-18 公開日 2010-06-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement. Proc.Natl.Acad.Sci.USA, 107, 2010
3LNM	F233W mutant of the Kv2.1 paddle-Kv1.2 chimera channel 分子名称: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, F233W mutant of the Kv2.1 paddle-Kv1.2 chimera, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Tao, X, Lee, A, Limapichat, W, Dougherty, D.A, MacKinnon, R. 登録日 2010-02-02 公開日 2010-04-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A gating charge transfer center in voltage sensors. Science, 328, 2010
3LN3	Crystal structure of Putative reductase (NP_038806.2) from MUS MUSCULUS at 1.18 A resolution 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrodiol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Joint Center for Structural Genomics (JCSG) 登録日 2010-02-01 公開日 2010-02-16 最終更新日 2019-07-17 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Crystal structure of Putative reductase (NP_038806.2) from MUS MUSCULUS at 1.18 A resolution To be published
2WZM	Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form 分子名称: ALDO-KETO REDUCTASE, [(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE 著者 Scoble, J, McAlister, A.D, Fulton, Z, Troy, S, Byres, E, Vivian, J.P, Brammananth, R, Wilce, M.C.J, Le Nours, J, Zaker-Tabrizi, L, Coppel, R.L, Crellin, P.K, Rossjohn, J, Beddoe, T. 登録日 2009-11-30 公開日 2010-02-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Crystal Structure and Comparative Functional Analyses of a Mycobacterium Aldo-Keto Reductase. J.Mol.Biol., 398, 2010
2WZT	Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form 分子名称: ALDO-KETO REDUCTASE 著者 Scoble, J, McAlister, A.D, Fulton, Z, Troy, S, Byres, E, Vivian, J.P, Brammananth, R, Wilce, M.C.J, Le Nours, J, Zaker-Tabrizi, L, Coppel, R.L, Crellin, P.K, Rossjohn, J, Beddoe, T. 登録日 2009-12-03 公開日 2010-02-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure and Comparative Functional Analyses of a Mycobacterium Aldo-Keto Reductase. J.Mol.Biol., 398, 2010
3GUG	Crystal structure of AKR1C1 L308V mutant in complex with NADP and 3,5-dichlorosalicylic acid 分子名称: 3,5-dichloro-2-hydroxybenzoic acid, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Dhagat, U, El-Kabbani, O. 登録日 2009-03-30 公開日 2010-02-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of AKR1C1 L308V mutant in complex with NADP and 3,5-dichlorosalicylic acid To be Published
3FX4	Porcine aldehyde reductase in ternary complex with inhibitor 分子名称: Alcohol dehydrogenase [NADP+], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... 著者 Carbone, V, El-Kabbani, O. 登録日 2009-01-20 公開日 2009-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor. Eur.J.Med.Chem., 45, 2010
3KRB	Structure of Aldose Reductase from Giardia Lamblia at 1.75A Resolution 分子名称: 1,2-ETHANEDIOL, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2009-11-18 公開日 2009-12-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure of aldose reductase from Giardia lamblia. Acta Crystallogr.,Sect.F, 67, 2011
3FJN	The crystal structure of 17-alpha hydroxysteroid dehydrogenase Y224D mutant. 分子名称: ACETATE ION, Aldo-keto reductase family 1 member C21 著者 Dhagat, U, El-Kabbani, O. 登録日 2008-12-14 公開日 2009-11-24 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme Acta Crystallogr.,Sect.D, 66, 2010
3H7U	Crystal structure of the plant stress-response enzyme AKR4C9 分子名称: ACETATE ION, Aldo-keto reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 White, S.A, Simpson, P.J, Ride, J.P. 登録日 2009-04-28 公開日 2009-08-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Characterization of two novel aldo-keto reductases from Arabidopsis: expression patterns, broad substrate specificity, and an open active-site structure suggest a role in toxicant metabolism following stress. J.Mol.Biol., 392, 2009
3H7R	Crystal structure of the plant stress-response enzyme AKR4C8 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Aldo-keto reductase, ... 著者 White, S.A, Simpson, P.J, Ride, J.P. 登録日 2009-04-28 公開日 2009-08-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Characterization of two novel aldo-keto reductases from Arabidopsis: expression patterns, broad substrate specificity, and an open active-site structure suggest a role in toxicant metabolism following stress. J.Mol.Biol., 392, 2009
3G1R	Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and Finasteride. Resolution 1.70 A 分子名称: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide, 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Di Costanzo, L, Drury, J.E, Penning, T.M, Christianson, D.W. 登録日 2009-01-30 公開日 2009-06-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.701 Å) 主引用文献 Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex. J.Biol.Chem., 284, 2009
3H4G	Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor Fidarestat: Implications for inhibitor binding and selectivity 分子名称: (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Alcohol dehydrogenase [NADP+], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Carbone, V, El-Kabbani, O. 登録日 2009-04-20 公開日 2009-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity J.Med.Chem., 48, 2005

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