The crystal structure of 17-alpha hydroxysteroid dehydrogenase Y224D mutant.

Summary for 3FJN

DescriptorAldo-keto reductase family 1 member C21, ACETATE ION (3 entities in total)
Functional Keywordsaldo-keto reductase, 17-alpha-hydroxysteroid dehydrogenase, cytoplasm, lipid metabolism, nadp, oxidoreductase, phosphoprotein, steroid metabolism
Biological sourceMus musculus (mouse)
Cellular locationCytoplasm (By similarity) Q91WR5
Total number of polymer chains2
Total molecular weight73989.16
Dhagat, U.,El-Kabbani, O. (deposition date: 2008-12-14, release date: 2009-11-24, Last modification date: 2011-07-13)
Primary citation
Dhagat, U.,Endo, S.,Mamiya, H.,Hara, A.,El-Kabbani, O.
Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme
Acta Crystallogr.,Sect.D, 66:198-204, 2010
PubMed: 20124700 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444909051464
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.276150.3%5.7%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report