3G1R

Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and Finasteride. Resolution 1.70 A

Summary for 3G1R

Entry DOI	10.2210/pdb3g1r/pdb
Descriptor	3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide, ... (4 entities in total)
Functional Keywords	finasteride complex, bile acid catabolism, cytoplasm, disease mutation, intrahepatic cholestasis, lipid metabolism, nadp, oxidoreductase, steroid metabolism
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	81057.87
Authors	Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W. (deposition date: 2009-01-30, release date: 2009-06-09, Last modification date: 2023-09-06)
Primary citation	Drury, J.E.,Di Costanzo, L.,Penning, T.M.,Christianson, D.W. Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex. J.Biol.Chem., 284:19786-19790, 2009 Cited by PubMed: 19515843 DOI: 10.1074/jbc.C109.016931 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.701 Å)

Structure validation