3LZ3

Human aldose reductase mutant T113S complexed with IDD388

Summary for 3LZ3

Entry DOI	10.2210/pdb3lz3/pdb
Related	2IKI 3LBO 3LD5 3LEN 3LEP 3LQG 3LZ5 3M4H
Descriptor	Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID, ... (6 entities in total)
Functional Keywords	t113s mutant, tim barrel, oxidoreductase, nadp, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37316.37
Authors	Koch, C.,Heine, A.,Klebe, G. (deposition date: 2010-03-01, release date: 2010-12-15, Last modification date: 2024-03-20)
Primary citation	Koch, C.,Heine, A.,Klebe, G. Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors J.Mol.Biol., 406:700-712, 2011 Cited by PubMed: 21185307 DOI: 10.1016/j.jmb.2010.11.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.03 Å)

Structure validation