3H4G

Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor Fidarestat: Implications for inhibitor binding and selectivity

Replaces:  2AO0

Summary for 3H4G

Related1PWM 3CV7
DescriptorAlcohol dehydrogenase [NADP+], SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywordstim barrel, aldo-keto reductase, ternary complex, nadp, oxidoreductase
Biological sourceSus scrofa (pigs)
Total number of polymer chains1
Total molecular weight37745.65
Authors
Carbone, V.,El-Kabbani, O. (deposition date: 2009-04-20, release date: 2009-05-05, Last modification date: 2011-07-13)
Primary citation
El-Kabbani, O.,Carbone, V.,Darmanin, C.,Oka, M.,Mitschler, A.,Podjarny, A.,Schulze-Briese, C.,Chung, R.P.
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
J.Med.Chem., 48:5536-5542, 2005
PubMed: 16107153 (PDB entries with the same primary citation)
DOI: 10.1021/jm050412o
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.216903.3%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3h4g
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Molmil generated image of 3h4g
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Molmil generated image of 3h4g
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