PDB: 7742 件ウェブページステータス検索Chemie searchBIRD

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3MP2	Crystal structure of transmissible gastroenteritis virus papain-like protease 1 分子名称: Non-structural protein 3, ZINC ION 著者 Wojdyla, J.A, Manolaridis, I, Tucker, P.A. 登録日 2010-04-24 公開日 2010-09-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates. J.Virol., 84, 2010
3M1F	Crosslinked complex of actin with first W domain of Vibrio parahaemolyticus VopL 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... 著者 Namgoong, S, Dominguez, R. 登録日 2010-03-04 公開日 2010-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structure of a longitudinal actin dimer assembled by tandem w domains: implications for actin filament nucleation. J.Mol.Biol., 403, 2010
3M36	Factor XA in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423) 分子名称: 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide, CALCIUM ION, Coagulation factor X 著者 Alexander, R.S. 登録日 2010-03-08 公開日 2010-04-21 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N-[3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor J.Med.Chem., 46, 2003
4DQV	Crystal structure of reductase (R) domain of non-ribosomal peptide synthetase from Mycobacterium tuberculosis 分子名称: PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE) 著者 Haque, A.S, Panjikar, S, Sankaranarayanan, R. 登録日 2012-02-16 公開日 2012-06-20 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetases. Proc.Natl.Acad.Sci.USA, 109, 2012
3L59	Structure of BACE Bound to SCH710413 分子名称: (2Z)-3-(3-chlorobenzyl)-2-imino-5,5-dimethylimidazolidin-4-one, Beta-secretase 1, D(-)-TARTARIC ACID 著者 Strickland, C, Zhu, Z. 登録日 2009-12-21 公開日 2010-02-16 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation J.Med.Chem., 53, 2010
3KYN	Crystal structure of HLA-G presenting KGPPAALTL peptide 分子名称: Beta-2-microglobulin, CHLORIDE ION, COBALT (II) ION, ... 著者 Walpole, N.G, Rossjohn, J, Clements, C.S. 登録日 2009-12-06 公開日 2010-02-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The structure and stability of the monomorphic HLA-G are influenced by the nature of the bound peptide J.Mol.Biol., 397, 2010
3PEP	REVISED 2.3 ANGSTROMS STRUCTURE OF PORCINE PEPSIN. EVIDENCE FOR A FLEXIBLE SUBDOMAIN 分子名称: ETHANOL, PEPSIN 著者 Abad-Zapatero, C, Erickson, J.W. 登録日 1989-10-24 公開日 1990-04-15 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Revised 2.3 A structure of porcine pepsin: evidence for a flexible subdomain Proteins, 8, 1990
3IXJ	Crystal structure of beta-secretase 1 in complex with selective beta-secretase 1 inhibitor 分子名称: Beta-secretase 1, N-[4-(1-BENZYLCARBAMOYL-2-METHYL-PROPYLCARBAMOYL)-1-(3,5-DIFLUORO-PHENOXYMETHYL)-2-HYDROXY-4-METHOXY-BUTYL]-5-(METHANESULFONYL-METHYL-AMINO)-N'-(1-PHENYLETHYL)-ISOPHTHALAMIDE, SULFATE ION 著者 Borkakoti, N, Lindberg, J, Nystrom, S. 登録日 2009-09-04 公開日 2010-03-02 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Design and Synthesis of Potent and Selective BACE-1 Inhibitors. J.Med.Chem., 53, 2010
4RMF	Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target 分子名称: 2,2-bis(hydroxymethyl)propane-1,3-diol, Aspartate--tRNA(Asp/Asn) ligase, FORMIC ACID 著者 Cox, J.A.G, Gurcha, S.S, Veeraraghavan, U, Besra, G.S, Futterer, K. 登録日 2014-10-21 公開日 2014-11-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target. Plos One, 9, 2014
3MVT	Crystal structure of apo mADA at 2.2A resolution 分子名称: Adenosine deaminase, CHLORIDE ION, GLYCEROL 著者 Niu, W, Shu, Q, Chen, Z, Mathews, S, Di Cera, E, Frieden, C. 登録日 2010-05-04 公開日 2010-10-13 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The role of Zn2+ on the structure and stability of murine adenosine deaminase. J.Phys.Chem.B, 114, 2010
4F7U	The 6S snRNP assembly intermediate 分子名称: HEXAETHYLENE GLYCOL, Methylosome subunit pICln, Small nuclear ribonucleoprotein E, ... 著者 Grimm, C, Pelz, J.P. 登録日 2012-05-16 公開日 2013-01-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.898 Å) 主引用文献 Structural Basis of Assembly Chaperone- Mediated snRNP Formation. Mol.Cell, 49, 2013
4J70	Yeast 20S proteasome in complex with the belactosin derivative 3e 分子名称: Proteasome component C1, Proteasome component C11, Proteasome component C5, ... 著者 Kawamura, S, Unno, Y, List, A, Tanaka, M, Sasaki, T, Arisawa, M, Asai, A, Groll, M, Shuto, S. 登録日 2013-02-12 公開日 2013-04-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Potent Proteasome Inhibitors Derived from the Unnatural cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action. J.Med.Chem., 56, 2013
3BA0	Crystal structure of full-length human MMP-12 分子名称: ACETOHYDROXAMIC ACID, CALCIUM ION, Macrophage metalloelastase, ... 著者 Bertini, I, Calderone, V, Fragai, M, Jaiswal, R, Luchinat, C, Melikian, M, Myonas, E, Svergun, D.I. 登録日 2007-11-07 公開日 2008-07-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12. J.Am.Chem.Soc., 130, 2008
3HYG	Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound 分子名称: (2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide, A disintegrin and metalloproteinase with thrombospondin motifs 5, CALCIUM ION, ... 著者 Shieh, H.-S, Williams, J.M, Caspers, N, Mathis, K.J, Tortorella, M.D, Tomasselli, A. 登録日 2009-06-22 公開日 2009-07-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors J.Biol.Chem., 284, 2009
4GWM	Crystal structure of human promeprin beta 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... 著者 Arolas, J.L, Broder, C, Jefferson, T, Guevara, T, Sterchi, E.E, Bode, W, Stocker, W, Becker-Pauly, C, Gomis-Ruth, F.X. 登録日 2012-09-03 公開日 2012-09-19 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane Proc.Natl.Acad.Sci.USA, 109, 2012
4HWZ	Structure of HLA-A68 complexed with an HIV derived peptide 分子名称: 9-mer peptide from Pol protein, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... 著者 Niu, L, Cheng, H, Zhang, S, Tan, S, Zhang, Y, Qi, J, Liu, J, Gao, G.F. 登録日 2012-11-09 公開日 2013-10-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.397 Å) 主引用文献 Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes Mol.Immunol., 55, 2013
3OF6	Human pre-T cell receptor crystal structure 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Pre T-cell antigen receptor alpha, T cell receptor beta chain 著者 Pang, S.S. 登録日 2010-08-13 公開日 2010-10-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The structural basis for autonomous dimerization of the pre-T-cell antigen receptor Nature, 467, 2010
4I48	Structure of HLA-A68 complexed with an HIV Env derived peptide 分子名称: 9-mer peptide from Envelope glycoprotein gp160, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... 著者 Niu, L, Cheng, H, Zhang, S, Tan, S, Zhang, Y, Qi, J, Liu, J, Gao, G.F. 登録日 2012-11-27 公開日 2013-10-02 実験手法 X-RAY DIFFRACTION (2.799 Å) 主引用文献 Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes Mol.Immunol., 55, 2013
4O03	Crystal structure of Ca2+ bound prothrombin deletion mutant residues 146-167 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Prothrombin 著者 Pozzi, N, Chen, Z, Shropshire, D.B, Pelc, L.A, Di Cera, E. 登録日 2013-12-13 公開日 2014-05-21 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3.38 Å) 主引用文献 The linker connecting the two kringles plays a key role in prothrombin activation. Proc.Natl.Acad.Sci.USA, 111, 2014
3Q4D	Crystal structure of dipeptide epimerase from Cytophaga hutchinsonii complexed with Mg and dipeptide D-Ala-L-Ala 分子名称: ALANINE, D-ALANINE, MAGNESIUM ION, ... 著者 Lukk, T, Gerlt, J.A, Nair, S.K. 登録日 2010-12-23 公開日 2011-02-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily. Proc.Natl.Acad.Sci.USA, 109, 2012
3L58	Structure of BACE Bound to SCH589432 分子名称: Beta-secretase 1, N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE 著者 Strickland, C, Zhu, Z. 登録日 2009-12-21 公開日 2010-02-16 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation J.Med.Chem., 53, 2010
4DCD	1.6A resolution structure of PolioVirus 3C Protease Containing a covalently bound dipeptidyl inhibitor 分子名称: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Genome polyprotein, ... 著者 Lovell, S, Battaile, K.P, Kim, Y, Tiew, K.-C, Mandadapu, S.R, Alliston, K.R, Groutas, W.C, Chang, K.O. 登録日 2012-01-17 公開日 2012-09-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses. J.Virol., 86, 2012
4NZQ	Crystal structure of Ca2+-free prothrombin deletion mutant residues 146-167 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin 著者 Pozzi, N, Chen, Z, Shropshire, D.B, Pelc, L.A, Di Cera, E. 登録日 2013-12-12 公開日 2014-05-21 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.807 Å) 主引用文献 The linker connecting the two kringles plays a key role in prothrombin activation. Proc.Natl.Acad.Sci.USA, 111, 2014
3HY7	Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat 分子名称: (2S,3R)-N~4~-[(1S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N~1~,2-dihydroxy-3-(2-methylpropyl)butanediamide, A disintegrin and metalloproteinase with thrombospondin motifs 5, CALCIUM ION, ... 著者 Shieh, H.-S, Williams, J.M, Caspers, N, Mathis, K.J, Tortorella, M.D, Tomasselli, A. 登録日 2009-06-22 公開日 2009-07-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors J.Biol.Chem., 284, 2009
4TWW	Structure of SARS-3CL protease complex with a Bromobenzoyl (S,R)-N-decalin type inhibitor 分子名称: (2S)-2-({[(3S,4aR,8aS)-2-(4-bromobenzoyl)decahydroisoquinolin-3-yl]methyl}amino)-3-(1H-imidazol-5-yl)propanal, 3C-like proteinase 著者 Akaji, K, Teruya, K, Shimamoto, Y, Sanjho, A, Yamashita, E, Nakagawa, A. 登録日 2014-07-02 公開日 2015-02-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors Bioorg.Med.Chem., 23, 2015

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