4J70

Yeast 20S proteasome in complex with the belactosin derivative 3e

Summary for 4J70

Entry DOI	10.2210/pdb4j70/pdb
Related	1RYP 3E47 3TDD
Related PRD ID	PRD_000915
Descriptor	Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
Functional Keywords	proteasome, drug discovery, irreversible inhibition, beta-lactone, ntn hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Saccharomyces cerevisiae (Baker's yeast) More
Cellular location	Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains	28
Total formula weight	729671.38
Authors	Kawamura, S.,Unno, Y.,List, A.,Tanaka, M.,Sasaki, T.,Arisawa, M.,Asai, A.,Groll, M.,Shuto, S. (deposition date: 2013-02-12, release date: 2013-04-17, Last modification date: 2023-09-20)
Primary citation	Kawamura, S.,Unno, Y.,List, A.,Mizuno, A.,Tanaka, M.,Sasaki, T.,Arisawa, M.,Asai, A.,Groll, M.,Shuto, S. Potent Proteasome Inhibitors Derived from the Unnatural cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action. J.Med.Chem., 56:3689-3700, 2013 Cited by PubMed: 23547757 DOI: 10.1021/jm4002296 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation