6IW1
| |
6IW4
| |
1TQC
| Ovine recombinant PrP(114-234), ARR variant in complex with the VRQ14 Fab fragment (IgG2a) | 分子名称: | VRQ14 Fab Heavy chain, VRQ14 Fab light chain, prion protein | 著者 | Eghiaian, F, Grosclaude, J, Lesceu, S, Debey, P, Doublet, B, Treguer, E, Rezaei, H, Knossow, M. | 登録日 | 2004-06-17 | 公開日 | 2004-07-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants Proc.Natl.Acad.Sci.USA, 101, 2004
|
|
1A14
| COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 5 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NC10 FV (HEAVY CHAIN), ... | 著者 | Malby, R.L, Mccoy, A.J, Kortt, A.A, Hudson, P.J, Colman, P.M. | 登録日 | 1997-12-21 | 公開日 | 1998-05-13 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Three-dimensional structures of single-chain Fv-neuraminidase complexes. J.Mol.Biol., 279, 1998
|
|
5UEM
| Crystal structure of 354NC37 Fab in complex with HIV-1 clade AE strain 93TH057 gp120 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 354NC37 Fab Heavy Chain, ... | 著者 | Sievers, S.A, Gristick, H.B, Bjorkman, P.J. | 登録日 | 2017-01-02 | 公開日 | 2018-01-10 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller. Sci Transl Med, 9, 2017
|
|
5UEL
| Crystal structure of 354NC102 Fab | 分子名称: | 354NC102 Fab Heavy Chain, 354NC102 Fab Light Chain, SULFATE ION | 著者 | Sievers, S.A, Gristick, H.B, Bjorkman, P.J. | 登録日 | 2017-01-02 | 公開日 | 2017-02-01 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller. Sci Transl Med, 9, 2017
|
|
5UD9
| Crystal structure of 354BG18 Fab | 分子名称: | Fab heavy chain, Light chain | 著者 | Scharf, L, Bjorkman, P.J. | 登録日 | 2016-12-23 | 公開日 | 2017-02-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller. Sci Transl Med, 9, 2017
|
|
6Y4M
| Structure of Tubulin Tyrosine Ligase in Complex with Tb111 | 分子名称: | (2~{R})-1-methylpiperidine-2-carboxylic acid, (2~{S},4~{R})-4-azanyl-2-methyl-5-phenyl-pentanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | 著者 | Gavrilyuk, J, Nocek, B, Rigol, S, Nicolaou, K.C, Stoll, V. | 登録日 | 2020-02-21 | 公開日 | 2021-03-31 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (3.34 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis. J.Org.Chem., 86, 2021
|
|
6Y4N
| Structure of Tubulin Tyrosine Ligase in Complex with Tb116 | 分子名称: | (2~{R})-1-methylpiperidine-2-carboxylic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Gavrilyuk, J, Nocek, B, Rigol, S, Nicolaou, K.C, Stoll, V. | 登録日 | 2020-02-21 | 公開日 | 2021-03-31 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.852 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis. J.Org.Chem., 86, 2021
|
|
8U31
| Crystal structure of PD-1 in complex with a Fab | 分子名称: | Fab heavy chain, Fab light chain, GLYCEROL, ... | 著者 | Sun, D, Masureel, M. | 登録日 | 2023-09-07 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. Mabs, 16, 2024
|
|
8U32
| Crystal structure of PD-1 in complex with a Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ... | 著者 | Sun, D, Masureel, M. | 登録日 | 2023-09-07 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. Mabs, 16, 2024
|
|
6T3F
| Crystal structure Nipah virus fusion glycoprotein in complex with a neutralising Fab fragment | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab66 heavy chain, ... | 著者 | Avanzato, V.A, Pryce, R, Walter, T.S, Bowden, T.A. | 登録日 | 2019-10-10 | 公開日 | 2019-11-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
4DGI
| Structure of POM1 FAB fragment complexed with human PrPc Fragment 120-230 | 分子名称: | Major prion protein, POM1 Fab Heavy chain, POM1 Fab Light chain, ... | 著者 | Baral, P.K, Wieland, B, Swayampakula, M, James, M.N. | 登録日 | 2012-01-26 | 公開日 | 2012-10-31 | 最終更新日 | 2013-01-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1. Acta Crystallogr.,Sect.D, 68, 2012
|
|
5A3I
| Crystal Structure of a Complex formed between FLD194 Fab and Transmissible Mutant H5 Haemagglutinin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTI-HAEMAGGLUTININ HA1 FAB HEAVY CHAIN, ... | 著者 | Xiong, X, Corti, D, Liu, J, Pinna, D, Foglierini, M, Calder, L.J, Martin, S.R, Lin, Y.P, Walker, P.A, Collins, P.J, Monne, I, Suguitan Jr, A.L, Santos, C, Temperton, N.J, Subbarao, K, Lanzavecchia, A, Gamblin, S.J, Skehel, J.J. | 登録日 | 2015-06-01 | 公開日 | 2015-07-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Structures of Complexes Formed by H5 Influenza Hemagglutinin with a Potent Broadly Neutralizing Human Monoclonal Antibody. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
1XF4
| Structure of ligand-free Fab DNA-1 in space group P321 solved from crystals with perfect hemihedral twinning | 分子名称: | Fab heavy chain, Fab light chain, SULFATE ION | 著者 | Schuermann, J.P, Prewitt, S.P, Deutscher, S.L, Tanner, J.J. | 登録日 | 2004-09-13 | 公開日 | 2005-04-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Evidence for Structural Plasticity of Heavy Chain Complementarity-determining Region 3 in Antibody-ssDNA Recognition J.Mol.Biol., 347, 2005
|
|
1XF3
| Structure of ligand-free Fab DNA-1 in space group P65 | 分子名称: | Fab Light chain, Fab heavy chain | 著者 | Schuermann, J.P, Prewitt, S.P, Deutscher, S.L, Tanner, J.J. | 登録日 | 2004-09-13 | 公開日 | 2005-04-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Evidence for Structural Plasticity of Heavy Chain Complementarity-determining Region 3 in Antibody-ssDNA Recognition J.Mol.Biol., 347, 2005
|
|
4R2G
| |
6WAS
| Structure of D19.PA8 Fab in complex with 1FD6 16055 V1V2 scaffold | 分子名称: | 1FD6 16055 V1V2 scaffold, 2-acetamido-2-deoxy-beta-D-glucopyranose, GN1_PA8 Fab Heavy chain, ... | 著者 | Singh, S, Liban, T.J, Pancera, M. | 登録日 | 2020-03-26 | 公開日 | 2021-03-31 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | 主引用文献 | Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization. Plos Pathog., 17, 2021
|
|
1KCU
| CRYSTAL STRUCTURE OF ANTIBODY PC287 | 分子名称: | PC287 IMMUNOGLOBULIN | 著者 | Nair, D.T, Singh, K, Siddiqui, Z, Nayak, B.P, Rao, K.V.S, Salunke, D.M. | 登録日 | 2001-11-11 | 公開日 | 2002-05-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response. J.Immunol., 168, 2002
|
|
1KCV
| Crystal structure of antibody pc282 | 分子名称: | PC282 IMMUNOGLOBULIN | 著者 | Nair, D.T, Singh, K, Siddiqui, Z, Nayak, B.P, Rao, K.V, Salunke, D.M. | 登録日 | 2001-11-11 | 公開日 | 2002-05-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response. J.Immunol., 168, 2002
|
|
2NY4
| HIV-1 gp120 Envelope Glycoprotein (K231C, T257S, E268C, S334A, S375W) Complexed with CD4 and Antibody 17b | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ... | 著者 | Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D. | 登録日 | 2006-11-20 | 公開日 | 2007-02-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature, 445, 2007
|
|
2NY7
| HIV-1 gp120 Envelope Glycoprotein Complexed with the Broadly Neutralizing CD4-Binding-Site Antibody b12 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY b12, HEAVY CHAIN, ... | 著者 | Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D. | 登録日 | 2006-11-20 | 公開日 | 2007-02-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature, 445, 2007
|
|
2NY3
| HIV-1 gp120 Envelope Glycoprotein (K231C, T257S, E267C, S334A, S375W) Complexed with CD4 and Antibody 17b | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ... | 著者 | Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D. | 登録日 | 2006-11-20 | 公開日 | 2007-02-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature, 445, 2007
|
|
2NY2
| HIV-1 gp120 Envelope Glycoprotein (T123C, T257S, S334A, S375W, G431C) Complexed with CD4 and Antibody 17b | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, ... | 著者 | Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D. | 登録日 | 2006-11-20 | 公開日 | 2007-02-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature, 445, 2007
|
|
2NXY
| HIV-1 gp120 Envelope Glycoprotein(S334A) Complexed with CD4 and Antibody 17b | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, ... | 著者 | Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D. | 登録日 | 2006-11-20 | 公開日 | 2007-02-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature, 445, 2007
|
|