6Y4M

Structure of Tubulin Tyrosine Ligase in Complex with Tb111

Summary for 6Y4M

• Entry DOI: 10.2210/pdb6y4m/pdb
• Descriptor: Tubulin alpha-1B chain, (2~{R})-1-methylpiperidine-2-carboxylic acid, [(1~{R},3~{R})-1-acetyloxy-1-[4-methanoyl-5-(2-phenylmethoxyethyl)-2,3-dihydro-1,3-thiazol-2-yl]-4-methyl-pentan-3-yl]-methyl-azanium, ... (16 entities in total)
• Functional Keywords: ttl, tubulin, ligase, complex
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265376.99

Authors

Gavrilyuk, J.,Nocek, B.,Rigol, S.,Nicolaou, K.C.,Stoll, V. (deposition date: 2020-02-21, release date: 2021-03-31, Last modification date: 2022-11-23)

• Primary citation: Nicolaou, K.C.,Pan, S.,Pulukuri, K.K.,Ye, Q.,Rigol, S.,Erande, R.D.,Vourloumis, D.,Nocek, B.P.,Munneke, S.,Lyssikatos, J.,Valdiosera, A.,Gu, C.,Lin, B.,Sarvaiaya, H.,Trinidad, J.,Sandoval, J.,Lee, C.,Hammond, M.,Aujay, M.,Taylor, N.,Pysz, M.,Purcell, J.W.,Gavrilyuk, J.; Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis.; J.Org.Chem., 86:3377-3421, 2021; PubMed: 33544599; DOI: 10.1021/acs.joc.0c02755

Experimental method

X-RAY DIFFRACTION (3.34 Å)