6Y4M
Structure of Tubulin Tyrosine Ligase in Complex with Tb111
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (Pig) | Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain |
| 2 | B, D (B, D) | Tubulin beta chain | polymer | 445 | 49907.8 | 2 | UniProt (P02554) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (Pig) | Beta-tubulin |
| 3 | E (E) | Stathmin-4 | polymer | 143 | 16844.2 | 1 | UniProt (P63043) Pfam (PF00836) | Rattus norvegicus (Norway rat) | Stathmin-like protein B3,RB3 |
| 4 | F (F) | Tubulin-Tyrosine Ligase | polymer | 384 | 44378.5 | 1 | UniProt (E1BQ43) | Gallus gallus (Chicken) | |
| 5 | G, P, U (A, C, D) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 3 | Chemie (GTP) | |||
| 6 | H, K, Q, V (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 7 | I, R (A, C) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 8 | J (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 9 | L (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 10 | M (B) | (2~{R})-1-methylpiperidine-2-carboxylic acid | non-polymer | 143.2 | 1 | Chemie (O9B) | |||
| 11 | N (B) | [(1~{R},3~{R})-1-acetyloxy-1-[4-methanoyl-5-(2-phenylmethoxyethyl)-2,3-dihydro-1,3-thiazol-2-yl]-4-methyl-pentan-3-yl]-methyl-azanium | non-polymer | 421.6 | 1 | Chemie (O9H) | |||
| 12 | O (B) | (2~{S},4~{R})-4-azanyl-2-methyl-5-phenyl-pentanoic acid | non-polymer | 207.3 | 1 | Chemie (OH5) | |||
| 13 | S (C) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 14 | T (C) | VALINE | non-polymer | 117.1 | 1 | Chemie (VAL) | |||
| 15 | W (F) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 16 | AA, BA, X, Y, Z (D, E, A, B, C) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
E: 49 - 189 (UniProt: P63043)
F: 1 - 378 (UniProt: E1BQ43)
| PDB | External Database | Details |
|---|---|---|
| Met 47 | - | expression tag |
| Ala 48 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 379 | - | expression tag |
| His 380 | - | expression tag |
| His 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 261447.1 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3929.9 | |
| All* | Total formula weight | 265377.0 |
