4DGI

Structure of POM1 FAB fragment complexed with human PrPc Fragment 120-230

Summary for 4DGI

• Entry DOI: 10.2210/pdb4dgi/pdb
• Related: 1TQB 2W9E
• Descriptor: Major prion protein, POM1 Fab Heavy chain, POM1 Fab Light chain, ... (5 entities in total)
• Functional Keywords: prion, antibody, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Cytoplasm: P04156
• Total number of polymer chains: 3
• Total formula weight: 60017.31

Authors

Baral, P.K.,Wieland, B.,Swayampakula, M.,James, M.N. (deposition date: 2012-01-26, release date: 2012-10-31, Last modification date: 2013-01-23)

• Primary citation: Baral, P.K.,Wieland, B.,Swayampakula, M.,Polymenidou, M.,Rahman, M.H.,Kav, N.N.,Aguzzi, A.,James, M.N.; Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1.; Acta Crystallogr.,Sect.D, 68:1501-1512, 2012; PubMed: 23090399; DOI: 10.1107/S0907444912037328

Experimental method

X-RAY DIFFRACTION (2.4 Å)