1TQC

Ovine recombinant PrP(114-234), ARR variant in complex with the VRQ14 Fab fragment (IgG2a)

Summary for 1TQC

Related1TQB
Descriptorprion protein, VRQ14 Fab Heavy chain, VRQ14 Fab light chain, ... (4 entities in total)
Functional Keywordsprion, antibody, unknown function-immune system complex, unknown function/immune system
Biological sourceOvis aries (sheep)
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Cellular locationCell membrane; Lipid-anchor, GPI-anchor P23907
Total number of polymer chains3
Total molecular weight59163.89
Authors
Eghiaian, F.,Grosclaude, J.,Lesceu, S.,Debey, P.,Doublet, B.,Treguer, E.,Rezaei, H.,Knossow, M. (deposition date: 2004-06-17, release date: 2004-07-06, Last modification date: 2011-07-13)
Primary citation
Eghiaian, F.,Grosclaude, J.,Lesceu, S.,Debey, P.,Doublet, B.,Treguer, E.,Rezaei, H.,Knossow, M.
Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants
Proc.Natl.Acad.Sci.USA, 101:10254-10259, 2004
PubMed: 15240887 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0400014101
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers251.9%4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload