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2DXS
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Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor
分子名称: Genome polyprotein, N-[(13-CYCLOHEXYL-6,7-DIHYDROINDOLO[1,2-D][1,4]BENZOXAZEPIN-10-YL)CARBONYL]-2-METHYL-L-ALANINE
著者Adachi, T, Tsuruha, J, Doi, S, Murase, K, Ikegashira, K, Watanabe, S, Uehara, K, Orita, T, Nomura, A, Kamada, M.
登録日2006-08-30
公開日2006-12-26
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of Conformationally Constrained Tetracyclic Compounds as Potent Hepatitis C Virus NS5B RNA Polymerase Inhibitors
J.Med.Chem., 49, 2006
2IJD
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Crystal Structure of the Poliovirus Precursor Protein 3CD
分子名称: Picornain 3C, RNA-directed RNA polymerase, SULFATE ION, ...
著者Marcotte, L.L, Gohara, D.W, Filman, D.J, Hogle, J.M.
登録日2006-09-29
公開日2007-02-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of poliovirus 3CD: virally-encoded protease and precursor to the RNA-dependent RNA polymerase.
J.Virol., 81, 2007
2IJF
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Crystal Structure of the Poliovirus RNA-Dependent RNA Polymerase Fidelity Mutant 3Dpol G64S
分子名称: RNA-directed RNA polymerase
著者Marcotte, L.L, Gohara, D.G, Filman, D.J, Hogle, J.M.
登録日2006-09-29
公開日2007-02-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of poliovirus 3CD: virally-encoded protease and precursor to the RNA-dependent RNA polymerase.
J.Virol., 81, 2007
2IJN
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BU of 2ijn by Molmil
Isothiazoles as active-site inhibitors of HCV NS5B polymerase
分子名称: (2R,3R)-3-{[3,5-BIS(TRIFLUOROMETHYL)PHENYL]AMINO}-2-CYANO-3-THIOXOPROPANAMIDE, RNA polymerase NS5B
著者Yan, S, Yao, N.
登録日2006-09-29
公開日2006-11-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Isothiazoles as active-site inhibitors of HCV NS5B polymerase
Bioorg.Med.Chem.Lett., 17, 2007
2IM1
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BU of 2im1 by Molmil
Crystal structure of poliovirus polymerase complexed with CTP and Mn2+
分子名称: ACETIC ACID, CYTIDINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
著者Thompson, A.A, Peersen, O.B.
登録日2006-10-03
公開日2006-12-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions.
J.Mol.Biol., 366, 2007
2IM3
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BU of 2im3 by Molmil
Crystal structure of poliovirus polymerase complexed with UTP and Mn2+
分子名称: ACETIC ACID, MANGANESE (II) ION, SODIUM ION, ...
著者Thompson, A.A, Peersen, O.B.
登録日2006-10-03
公開日2006-12-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions.
J.Mol.Biol., 366, 2007
2IM2
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BU of 2im2 by Molmil
Crystal structure of poliovirus polymerase complexed with UTP and Mg2+
分子名称: ACETIC ACID, SODIUM ION, URIDINE 5'-TRIPHOSPHATE, ...
著者Thompson, A.A, Peersen, O.B.
登録日2006-10-03
公開日2006-12-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions.
J.Mol.Biol., 366, 2007
2ILZ
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BU of 2ilz by Molmil
Crystal structure of poliovirus polymerase complexed with GTP and Mn2+
分子名称: ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
著者Thompson, A.A, Peersen, O.B.
登録日2006-10-03
公開日2006-12-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions.
J.Mol.Biol., 366, 2007
2IM0
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BU of 2im0 by Molmil
Crystal structure of poliovirus polymerase complexed with CTP and Mg2+
分子名称: ACETIC ACID, CYTIDINE-5'-TRIPHOSPHATE, SODIUM ION, ...
著者Thompson, A.A, Peersen, O.B.
登録日2006-10-03
公開日2006-12-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions.
J.Mol.Biol., 366, 2007
2ILY
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BU of 2ily by Molmil
Crystal structure of poliovirus polymerase complexed with ATP and Mg2+
分子名称: ACETIC ACID, ADENOSINE-5'-TRIPHOSPHATE, Poliovirus polymerase, ...
著者Thompson, A.A, Peersen, O.B.
登録日2006-10-03
公開日2006-12-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions.
J.Mol.Biol., 366, 2007
2J7N
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BU of 2j7n by Molmil
Structure of the RNAi polymerase from Neurospora crassa
分子名称: GLYCEROL, MAGNESIUM ION, RNA-DEPENDENT RNA POLYMERASE
著者Salgado, P.S, Koivunen, M.R.L, Makeyev, E.V, Bamford, D.H, Stuart, D.I, Grimes, J.M.
登録日2006-10-13
公開日2006-12-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Structure of an Rnai Polymerase Links RNA Silencing and Transcription.
Plos Biol., 4, 2006
2J7O
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STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA
分子名称: MAGNESIUM ION, RNA DEPENDENT RNA POLYMERASE
著者Salgado, P.S, Koivunen, M.R.L, Makeyev, E.V, Bamford, D.H, Stuart, D.I, Grimes, J.M.
登録日2006-10-13
公開日2006-12-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献The Structure of an Rnai Polymerase Links RNA Silencing and Transcription.
Plos Biol., 4, 2006
2J7W
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BU of 2j7w by Molmil
Dengue virus NS5 RNA dependent RNA polymerase domain complexed with 3' dGTP
分子名称: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-TRIPHOSPHATE, POLYPROTEIN, ...
著者Yap, T.L, Xu, T, Chen, Y.L, Malet, H, Egloff, M.P, Canard, B, Vasudevan, S.G, Lescar, J.
登録日2006-10-17
公開日2007-03-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of the Dengue Virus RNA- Dependent RNA Polymerase Catalytic Domain at 1.85 Angstrom Resolution.
J.Virol., 81, 2007
2J7U
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Dengue virus NS5 RNA dependent RNA polymerase domain
分子名称: CHLORIDE ION, MAGNESIUM ION, RNA DEPENDENT RNA POLYMERASE, ...
著者Yap, T.L, Xu, T, Chen, Y.L, Malet, H, Egloff, M.P, Canard, B, Vasudevan, S.G, Lescar, J.
登録日2006-10-17
公開日2007-03-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of the Dengue Virus RNA- Dependent RNA Polymerase Catalytic Domain at 1.85 Angstrom Resolution.
J.Virol., 81, 2007
2NVQ
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BU of 2nvq by Molmil
RNA Polymerase II Elongation Complex in 150 mM Mg+2 with 2'dUTP
分子名称: 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-13
公開日2006-12-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2NVT
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RNA Polymerase II Elongation Complex in 150 mM Mg+2 with GMPCPP
分子名称: 5'-D(*GP*TP*AP*CP*TP*TP*G)-3', 5'-D(P*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*TP*GP*GP*TP*CP*TP*T)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-13
公開日2006-12-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.36 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2NVY
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BU of 2nvy by Molmil
RNA Polymerase II form II in 150 mM Mn+2
分子名称: DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 45 kDa polypeptide, ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-13
公開日2006-12-26
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2NVX
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RNA polymerase II elongation complex in 5 mM Mg+2 with 2'-dUTP
分子名称: 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-13
公開日2006-12-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2NVZ
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RNA Polymerase II elongation complex with UTP, updated 11/2006
分子名称: 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-14
公開日2006-12-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (4.3 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2E2J
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BU of 2e2j by Molmil
RNA polymerase II elongation complex in 5 mM Mg+2 with GMPCPP
分子名称: 27-MER DNA template strand, 5'-D(P*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*A)-3', 5'-R(P*AP*UP*CP*GP*AP*GP*AP*GP*G)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-14
公開日2006-12-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2E2H
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BU of 2e2h by Molmil
RNA polymerase II elongation complex at 5 mM Mg2+ with GTP
分子名称: 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-14
公開日2006-12-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.95 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2E2I
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BU of 2e2i by Molmil
RNA polymerase II elongation complex in 5 mM Mg+2 with 2'-dGTP
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-14
公開日2006-12-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.41 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
2JA5
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CPD lesion containing RNA Polymerase II elongation complex A
分子名称: 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *CP*TP*TTP*TP*TP*CP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP)-3', DNA-directed RNA polymerase II subunit RPB1, ...
著者Brueckner, F, Hennecke, U, Carell, T, Cramer, P.
登録日2006-11-23
公開日2007-02-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Cpd Damage Recognition by Transcribing RNA Polymerase II
Science, 315, 2007
2JA8
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CPD lesion containing RNA Polymerase II elongation complex D
分子名称: 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *CP*TP*TP*TP*TP*TTP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-D(*TP*AP*AP*GP*TP*AP*CP*TP*TP*GP *AP*GP*CP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*AP*UP)-3', ...
著者Brueckner, F, Hennecke, U, Carell, T, Cramer, P.
登録日2006-11-23
公開日2007-02-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Cpd Damage Recognition by Transcribing RNA Polymerase II.
Science, 315, 2007
2JA6
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CPD lesion containing RNA Polymerase II elongation complex B
分子名称: 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *CP*TP*TP*TTP*TP*CP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-D(*TP*AP*AP*GP*TP*AP*CP*TP*TP*GP *AP*GP*CP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP)-3', ...
著者Brueckner, F, Hennecke, U, Carell, T, Cramer, P.
登録日2006-11-23
公開日2007-02-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献CPD damage recognition by transcribing RNA polymerase II.
Science, 315, 2007

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