2DXS
Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor
Summary for 2DXS
Entry DOI | 10.2210/pdb2dxs/pdb |
Related | 1QUV |
Descriptor | Genome polyprotein, N-[(13-CYCLOHEXYL-6,7-DIHYDROINDOLO[1,2-D][1,4]BENZOXAZEPIN-10-YL)CARBONYL]-2-METHYL-L-ALANINE (3 entities in total) |
Functional Keywords | hcv, ns5b, rna polymerase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Hepatitis C virus |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663 |
Total number of polymer chains | 2 |
Total formula weight | 123607.73 |
Authors | Adachi, T.,Tsuruha, J.,Doi, S.,Murase, K.,Ikegashira, K.,Watanabe, S.,Uehara, K.,Orita, T.,Nomura, A.,Kamada, M. (deposition date: 2006-08-30, release date: 2006-12-26, Last modification date: 2023-10-25) |
Primary citation | Ikegashira, K.,Oka, T.,Hirashima, S.,Noji, S.,Yamanaka, H.,Hara, Y.,Adachi, T.,Tsuruha, J.,Doi, S.,Hase, Y.,Noguchi, T.,Ando, I.,Ogura, N.,Ikeda, S.,Hashimoto, H. Discovery of Conformationally Constrained Tetracyclic Compounds as Potent Hepatitis C Virus NS5B RNA Polymerase Inhibitors J.Med.Chem., 49:6950-6953, 2006 Cited by PubMed: 17125247DOI: 10.1021/jm0610245 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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